Suhayl J. Jabbur

TL;DR: The results indicate that the use of ET‐produced hyperalgesia is a valid model for local and reversible inflammatory pain, with minimal distress to the animal, and can also be used to study the efficacy of various anti‐inflammatory and analgesic drugs and the molecular mechanisms of inflammation induced by bacterial invasion.

TL;DR: The results suggest that the dopaminergic system plays a major role in the processing of nociceptive information in the striatum and the limbic areas.

TL;DR: It is speculated that neuropathic pain, like extrapyramidal motor syndromes, reflects a disorder in the processing of somatosensory information.

TL;DR: Dorsal column nuclear stimulation, rostral to selective dorsal spinal lesions, produced strong inhibitory effects on the allodynia and hyperalgesia observed in both models of mononeuropathy, comparable to those observed following similar stimulations in rats with an intact spinal cord.

TL;DR: It is suggested that both supraspinal and segmental mechanisms are activated by SCS, and that in this model with DC lesions, rostral and caudal stimulations may activate different synaptic circuitries and transmitter systems.