Suhua Zhu

TL;DR: The biogenesis and components of exosomes mainly in lung cancer, their function in lung carcinogenesis (epithelial mesenchymal transition, oncogenic cell transformation, angiogenesis, metastasis and immune response in tumor microenvironment) are described and their clinical potential is focused on.

TL;DR: The study uncovered that PTP1B can promote NSCLC proliferation and metastasis by activating src and subsequently ERK1/2 and provides a theoretical basis for future applications of PTP 1B inhibitors in the treatment ofNSCLC.

TL;DR: It is shown that carboplatin can induce DNA damage and activate the canonical STING/TBK1/IRF3 pathway and non-canonical STING-NF-κB signaling complex and that knocking down STING in tumor cells effectively reversed PD-L1 upregulation and STING pathway activation.

TL;DR: This review covers some of the current issues related to the loop between platelets and tumor aggression, including the manners of tumor cells in "educating" Platelets and biofunctional alterations of platelets upon tumor "education".

TL;DR: It is suggested that inhibition of pulmonary GGPPS1 attenuated LPS-induced ALI predominantly by suppressing the NLRP3 inflammasome through Rab10-mediated TLR4 replenishment.