Showing papers in "Cancer Letters in 2021"

TL;DR: A review of recent advances in immunotherapy in osteosarcoma and discuss the mechanisms and status of immunotherapies in both preclinical and clinical trials as well as future therapies on the horizon is presented in this article.

TL;DR: In this paper, it has been shown that microRNAs (miRNAs) can dually inhibit/induce NF-κB signaling thereby affecting the growth and migration of cancer cells.

TL;DR: A review of the characteristics, types, biogenesis, and functions of circRNAs can be found in this article, where the authors outline a series of the most recently studied CircRNAs and their functional mechanisms in multiple cancer types with future perspectives.

TL;DR: In this article, the authors aimed to discern the causes that prevent resveratrol from being used in cancer treatment, including poor pharmacokinetics and low potency, which hinders its further development as an anticancer drug.

TL;DR: The representative studies of SDT-instructed multimodal synergistic cancer therapy are comprehensively presented and it is believed that such an emerging synergistic therapeutic modality based on SDT will play a more significant role in the field of tumor precision treatment medicine.

TL;DR: The latest advances in the mechanisms underlying TNBC therapeutic resistance are summarized, how these mechanisms may affect the development and utilization of TNBC targeted drugs are considered, and the rationale of relevant signals as therapeutic targets are discussed.

TL;DR: Innate antiviral activity of the APOBEC3 family members restrict retroviruses, endogenous retro-element, and DNA viruses including the HPV that is the leading risk factor for cervical cancer.

TL;DR: In this paper, the effects and underlying mechanisms of luteolin, apigenin, and anti-PD-1 antibody combined with luteolins or apigenins on the PD-L1 expression and anti tumorigenesis in KRASmutant lung cancer were investigated.

TL;DR: This review highlights the prospect of targeting the PIM as a potential strategy to improve therapeutic outcomes for cervical cancer and summarizes the current understanding of these key components, characteristics, and effects.

TL;DR: In this paper, the current status and temporal trends of colorectal cancer in China, Europe, and northern America are summarized and the potential primary preventive strategies and latest advances in CRC screening techniques and programs are discussed.

TL;DR: Clinically, the expression of ACSL4 was positively correlated with that of SREBP1 in HCC patients, and the combinational biomarkers showed strong predictive value for HCC, uncovering a new mechanism by which AC SL4 modulates aberrant lipid metabolism and promotes the progression of HCC.

TL;DR: In this paper, the rationale behind combining radiotherapy with ICB, a potential synergy through mutually beneficial remodelling of the tumour microenvironment (TME), is outlined. And ongoing efforts that combine radiation, immunotherapy and inhibitors of DNA damage response, which can help achieve a favorable equilibrium between the immunogenic and tolerogenic effects of radiation on the immune microenvironment.

TL;DR: A comprehensive and systematic literature review summarizes the advances in the epidemiology of pancreatic cancer, including its epidemiological trends, risk factors, risk prediction models, screening modalities, and prognosis as mentioned in this paper.

TL;DR: The role of PKM2 in different cancers as well as TME is introduced, and the molecular mechanism ofPKM2-related lncRNAs in cancer metabolism is summarized to help in developing therapeutic strategies in clinic for researchers.

TL;DR: The aim of this review is to provide a theoretical basis that might promote the discovery of more peptides/proteins encoded by ncRNAs and aid the further development of novel diagnostic and prognostic cancer markers and therapeutic targets.

TL;DR: Zhang et al. as discussed by the authors investigated the role and mechanism of the m6A writer METTL3 in regulating the malignant progression of IDH-wildtype gliomas.

TL;DR: Long noncoding RNAs (lncRNAs) are a class of RNAs that do not code for proteins but are critical in regulating diverse cellular processes and maintaining cell function as mentioned in this paper.

TL;DR: In this article, the authors summarized the complex crosstalk between short-chain fatty acids and colorectal cancer, which might inspire new approaches for the diagnosis, treatment and prevention of CRC on the basis of gut microbiota-derived metabolites SCFAs.

TL;DR: Lactate is the major byproduct of such metabolic alterations and consequently, accumulates in the tumour as mentioned in this paper, which can recruit and induce immunosuppressive cell types, such as regulatory T cells, tumour-associated macrophages, and myeloid-derived suppressor cells which further suppress anti-tumour immune responses.

TL;DR: It is indicated that NLRP3 inflammasome promotes immunosuppression by modulating PD-L1 and immune cells and in vivo studies revealed IL-18 as the main effector cytokine involved in the negative regulation of anti-lymphoma immunity.

TL;DR: In this paper, bovine colostrum exosomes and polyethyleneimine matrix (EPM) were used to deliver short interfering RNA (siRNA) or plasmid DNA (pDNA) for effective gene therapy.

TL;DR: In this paper, the authors observed that monocytic myeloid-derived suppressor cells (MDSCs) were correlated with cisplatin resistance in patients with esophageal squamous cell carcinoma (ESCC).

TL;DR: In this paper, the essential role of KLF2 in suppressing the metastasis of ccRCC was identified, which could be a promising target regarding to the therapies of advanced CCRCC in the clinic.

TL;DR: In this article, the authors highlight the role of 2-oxoglutarate-dependent dioxygenases in HIF1α retrograde signaling during pseudohypoxia and discuss how these changes affect both the development of cancers and their resistance to treatment.

TL;DR: The current understanding of the principal roles of CHK1 is expound and different avenues forCHK1 targeting in cancer therapy are highlighted.

TL;DR: NETs interact reciprocally with pancreatic cancer cells, which play a pivotal role in inflammation-associated metastasis, and targeting NETs with thrombomodulin can be a novel strategy to improve the surgical outcome of pancreaticcancer patients.

TL;DR: It is shown that carboplatin can induce DNA damage and activate the canonical STING/TBK1/IRF3 pathway and non-canonical STING-NF-κB signaling complex and that knocking down STING in tumor cells effectively reversed PD-L1 upregulation and STING pathway activation.

TL;DR: In this article, the authors reported that Helicobacter pylori-induced Programmed Death-Ligand 1 (PD-L1) expression within the gastric epithelium is mediated by the Hedgehog (Hh) signaling pathway.

TL;DR: It is found that YAP/TAZ-mediated repression of TGFBR2 occurs both: post-transcriptionally through the miR-106b-25 cluster and transcriptionally by engaging the EZH2 epigenetic repressor that is reported here as a novel target gene of YAP-TAZ.