S
Sui Huang
Researcher at Institute for Systems Biology
Publications - 177
Citations - 27031
Sui Huang is an academic researcher from Institute for Systems Biology. The author has contributed to research in topics: Gene regulatory network & Population. The author has an hindex of 67, co-authored 162 publications receiving 24885 citations. Previous affiliations of Sui Huang include Harvard University & Kavli Institute for Theoretical Physics.
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Journal ArticleDOI
Geometric control of cell life and death.
TL;DR: Human and bovine capillary endothelial cells were switched from growth to apoptosis by using micropatterned substrates that contained extracellular matrix-coated adhesive islands of decreasing size to progressively restrict cell extension.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Transcriptome-wide noise controls lineage choice in mammalian progenitor cells
Hannah H. Chang,Martin Hemberg,Martin Hemberg,Mauricio Barahona,Donald E. Ingber,Sui Huang,Sui Huang +6 more
TL;DR: Clonal heterogeneity of gene expression level is not due to independent noise in the expression of individual genes, but reflects metastable states of a slowly fluctuating transcriptome that is distinct in individual cells and may govern the reversible, stochastic priming of multipotent progenitor cells in cell fate decision.
Journal ArticleDOI
The structural and mechanical complexity of cell-growth control.
Sui Huang,Donald E. Ingber +1 more
TL;DR: Recent work is reviewed that reveals the importance of cell binding to the extracellular matrix, and associated changes in cell shape and cytoskeletal tension, to the spatial control of cell-cycle progression.
Journal ArticleDOI
Micropatterned Surfaces for Control of Cell Shape, Position, and Function
TL;DR: Progressively restricting bovine and human endothelial cell extension by culturing cells on smaller and smaller micropatterned adhesive islands regulated a transition from growth to apoptosis on a single continuum of cell spreading, thus confirming the central role of cell shape in cell function.