Showing papers by "Sukanta Saha published in 2018"
National Drug and Alcohol Research Centre1, University of Queensland2, University of California, Davis3, Pompeu Fabra University4, University of São Paulo5, Stony Brook University6, Katholieke Universiteit Leuven7, Universidade Nova de Lisboa8, University College Hospital, Ibadan9, University of Barcelona10, Paris Descartes University11, The Chinese University of Hong Kong12, University of Michigan13, Cayetano Heredia University14, Harvard University15, University of Otago16, University of Buenos Aires17, Utrecht University18, Virginia Commonwealth University19, Aarhus University20, Centre for Mental Health21
TL;DR: Associations between psychotic experiences (PEs) and substance use/substance use disorders (SU/SUDs) are often bidirectional, but not all types of SU/Suds are associated with PEs.
Abstract: Prior research has found bidirectional associations between psychotic experiences (PEs), and selected substance use disorders. We aimed to extend this research by examining the bidirectional association between PEs, and various types of substance use (SU), and substance use disorders (SUDs), and the influence of antecedent mental disorders on these associations. We used data from the World Health Organisation World Mental Health surveys. A total of 30,902 adult respondents across 18 countries were assessed for (a) six types of lifetime PEs, (b) a range of types of SU and DSM-IV SUDs, and (c) mental disorders using the Composite International Diagnostic Interview. Discrete-time survival analyses based on retrospective age-at-onset reports examined the bidirectional associations between PEs and SU/SUDs controlling for antecedent mental disorders. After adjusting for demographics, comorbid SU/SUDs and antecedent mental disorders, those with prior alcohol use disorders (OR=1.6, 95% CI=1.2-2.0), extra-medical prescription drug use (OR=1.5, 95% CI=1.1-1.9), alcohol use (OR=1.4, 95% CI=1.1-1.7), and tobacco use (OR=1.3, 95% CI=1.0-1.8) had increased odds of subsequent first onset of PEs. In contrast, those with temporally prior PEs had increased odds of subsequent onset of tobacco use (OR=1.5, 95% CI=1.2-1.9), alcohol use (OR=1.3, 95% CI=1.1-1.6) or cannabis use (OR=1.3, 95% CI=1.0-1.5) as well as of all substance use disorders (ORs ranged between 1.4 and 1.5). There was a dose response relationship between both count and frequency of PEs and increased subsequent odds of selected SU/SUDs. Associations between psychotic experiences (PEs) and substance use/substance use disorders (SU/SUDs) are often bidirectional, but not all types of SU/SUDs are associated with PEs. These findings suggest that it is important to be aware of the presence of PEs within those with SUDs or at risk of SUDs, given the plausibility that they may each impact upon the other.
52 citations
10 Sep 2018
TL;DR: This study aimed to investigate the association between PEs and measures of disability using the World Mental Health surveys to find out if psychotic experiences are associated with disability.
Abstract: While psychotic experiences (PEs) are known to be associated with a range of mental and general medical disorders, little is known about the association between PEs and measures of disability. We aimed to investigate this question using the World Mental Health surveys.
34 citations
University of Otago1, University of Queensland2, University of California, Davis3, Stony Brook University4, Katholieke Universiteit Leuven5, Universidade Nova de Lisboa6, University of Groningen7, National Drug and Alcohol Research Centre8, University College Hospital, Ibadan9, University of Barcelona10, University of Balamand11, EHESP12, The Chinese University of Hong Kong13, Paris Descartes University14, University of Michigan15, Cayetano Heredia University16, Harvard University17, University of Buenos Aires18
TL;DR: PEs were associated with the subsequent onset of a wide range of GMCs, independent of comorbid mental disorders, and clinicians should be aware that psychotic symptoms may be risk markers for a widerange of adverse health outcomes.
Abstract: BackgroundPrevious work has identified associations between psychotic experiences (PEs) and general medical conditions (GMCs), but their temporal direction remains unclear as does the extent to which they are independent of comorbid mental disorders.MethodsIn total, 28 002 adults in 16 countries from the WHO World Mental Health (WMH) Surveys were assessed for PEs, GMCs and 21 Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) mental disorders. Discrete-time survival analyses were used to estimate the associations between PEs and GMCs with various adjustments.ResultsAfter adjustment for comorbid mental disorders, temporally prior PEs were significantly associated with subsequent onset of 8/12 GMCs (arthritis, back or neck pain, frequent or severe headache, other chronic pain, heart disease, high blood pressure, diabetes and peptic ulcer) with odds ratios (ORs) ranging from 1.3 [95% confidence interval (CI) 1.1–1.5] to 1.9 (95% CI 1.4–2.4). In contrast, only three GMCs (frequent or severe headache, other chronic pain and asthma) were significantly associated with subsequent onset of PEs after adjustment for comorbid GMCs and mental disorders, with ORs ranging from 1.5 (95% CI 1.2–1.9) to 1.7 (95% CI 1.2–2.4).ConclusionsPEs were associated with the subsequent onset of a wide range of GMCs, independent of comorbid mental disorders. There were also associations between some medical conditions (particularly those involving chronic pain) and subsequent PEs. Although these findings will need to be confirmed in prospective studies, clinicians should be aware that psychotic symptoms may be risk markers for a wide range of adverse health outcomes. Whether PEs are causal risk factors will require further research.
32 citations
EHESP1, University of Queensland2, University of California, Davis3, Pompeu Fabra University4, University of Groningen5, University Medical Center Groningen6, Katholieke Universiteit Leuven7, University of Barcelona8, St George's Hospital9, University of Balamand10, University of Tokyo11, The Chinese University of Hong Kong12, Paris Descartes University13, University of Buenos Aires14, Utrecht University15, Universidade Federal do Espírito Santo16, Harvard University17, Aarhus University18
TL;DR: The aim of the study was to examine associations between psychotic experiences (PEs) and religiosity in a large, cross‐national sample.
Abstract: Objectives Religiosity is often associated with better health outcomes. The aim of the study was to examine associations between psychotic experiences (PEs) and religiosity in a large, cross-national sample. Methods A total of 25 542 adult respondents across 18 countries from the WHO World Mental Health Surveys were assessed for PEs, religious affiliation and indices of religiosity, DSM-IV mental disorders and general medical conditions. Logistic regression models were used to estimate the association between PEs and religiosity with various adjustments. Results Of 25 542 included respondents, 85.6% (SE = 0.3) (n = 21 860) respondents reported having a religious affiliation. Overall, there was no association between religious affiliation status and PEs. Within the subgroup having a religious affiliation, four of five indices of religiosity were significantly associated with increased odds of PEs (odds ratios ranged from 1.3 to 1.9). The findings persisted after adjustments for mental disorders and/or general medical conditions, as well as religious denomination type. There was a significant association between increased religiosity and reporting more types of PEs. Conclusions Among individuals with religious affiliations, those who reported more religiosity on four of five indices had increased odds of PEs. Focussed and more qualitative research will be required to unravel the interrelationship between religiosity and PEs.
23 citations
Pompeu Fabra University1, Centre for Mental Health2, University of California, Davis3, Stony Brook University4, National Drug and Alcohol Research Centre5, University College Hospital, Ibadan6, University of Barcelona7, St George's Hospital8, EHESP9, Paris Descartes University10, The Chinese University of Hong Kong11, University of Michigan12, Harvard University13, University of Otago14, University of Buenos Aires15, Utrecht University16, Universidade Federal do Espírito Santo17, Aarhus University18, University of Queensland19
TL;DR: The findings provide novel insights into how those with PEs perceive their health status and the associations between PEs and five HRQoL indicators with various adjustments are investigated.
20 citations