S
Sumesh P. Thampi
Researcher at Indian Institute of Technology Madras
Publications - 74
Citations - 2631
Sumesh P. Thampi is an academic researcher from Indian Institute of Technology Madras. The author has contributed to research in topics: Drop (liquid) & Particle. The author has an hindex of 21, co-authored 65 publications receiving 1983 citations. Previous affiliations of Sumesh P. Thampi include University of Oxford & Indian Institute of Technology Kanpur.
Papers
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Journal ArticleDOI
Topological defects in epithelia govern cell death and extrusion.
Thuan Beng Saw,Amin Doostmohammadi,Vincent Nier,Leyla Kocgozlu,Sumesh P. Thampi,Sumesh P. Thampi,Yusuke Toyama,Philippe Marcq,Chwee Teck Lim,Julia M. Yeomans,Benoit Ladoux +10 more
TL;DR: A mechanism for apoptotic cell extrusion is proposed: spontaneously formed topological defects in epithelia govern cell fate, and the ability to control extrusion hotspots by geometrically inducing defects through microcontact printing of patterned monolayers is demonstrated.
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Velocity correlations in an active nematic
TL;DR: The flow properties of a continuum model for an active nematic are studied and the velocity correlation length is found to be independent of the strength of the activity while the characteristic velocity scale increases monotonically as the activity is increased, both in agreement with the experimental observations.
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Stabilization of active matter by flow-vortex lattices and defect ordering.
TL;DR: It is demonstrated that the crossover between wet active systems, whose behaviour is dominated by hydrodynamics, and dry active matter where any flow is screened, can be achieved by using friction as a control parameter, and unexpected vortex ordering is discovered at this wet–dry crossover.
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Defect-mediated morphologies in growing cell colonies
TL;DR: It is shown that shape changes during the growth can be regulated by the dynamics of topological defects in the orientation of cells, and that the cells predominantly reorient parallel to the interface due to division-induced active stresses.
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Instabilities and topological defects in active nematics
TL;DR: In this paper, the authors study a continuum model of an extensile active nematic and show that mesoscale turbulence develops in two stages: ordered regions undergo an intrinsic hydrodynamic instability generating walls, lines of strong bend deformations; the walls relax by forming oppositely charged pairs of defects.