Thuan Beng Saw

TL;DR: A mechanism for apoptotic cell extrusion is proposed: spontaneously formed topological defects in epithelia govern cell fate, and the ability to control extrusion hotspots by geometrically inducing defects through microcontact printing of patterned monolayers is demonstrated.

TL;DR: In this paper, the authors discuss epithelial tissues as active materials with particular rheological properties and active behaviours at different length scales and highlight 2D and 3D materials for the study of epithelial dynamics and summarize key methods for probing epithelial mechanics.

TL;DR: It is shown that the experimentally measured flow field of dividing Madin-Darby Canine Kidney (MDCK) cells is reproduced by the modeling approach and the fingering instabilities induced by cell division are compared to experimental observations on the expansion of MDCK cell cultures.

TL;DR: The authors develop a method to study collective behaviour in lumenal structures and show that several features depend on the extent of tubular confinement and/or curvature.

TL;DR: This study provides a quantitative and robust framework to explain how cell density can influence tissue mechanics and in turn regulate cell extrusion mechanisms.