S
Sumit Das
Researcher at National Center for Charitable Statistics
Publications - 5
Citations - 227
Sumit Das is an academic researcher from National Center for Charitable Statistics. The author has contributed to research in topics: Cancer stem cell & Stem cell. The author has an hindex of 4, co-authored 5 publications receiving 122 citations.
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Journal ArticleDOI
Receptor tyrosine kinases (RTKs) in breast cancer: signaling, therapeutic implications and challenges
Ramesh Butti,Sumit Das,Vinoth Prasanna Gunasekaran,Amit S. Yadav,Dhiraj Kumar,Gopal C. Kundu +5 more
TL;DR: Multi-faceted role of RTKs renders them amenable to therapy in breast cancer, however, structural mutations, gene amplification and alternate pathway activation pose challenges to anti-RTK therapy.
Journal ArticleDOI
p53 gain-of-function mutations increase Cdc7-dependent replication initiation
Arindam Datta,Dishari Ghatak,Sumit Das,Taraswi Banerjee,Anindita Paul,Ramesh Butti,Mahadeo Gorain,Sangeeta Ghuwalewala,Anirban Roychowdhury,Sk Kayum Alam,Pijush K. Das,Raghunath Chatterjee,Maitrayee DasGupta,Chinmay Kumar Panda,Gopal C. Kundu,Susanta Roychoudhury +15 more
TL;DR: It is proposed that increased Cdc7‐dependent replication initiation is a hallmark of p53 gain‐of‐function mutations and predicts poor clinical outcome in lung adenocarcinoma patients.
Journal ArticleDOI
MiRNA-146a/AKT/β-Catenin Activation Regulates Cancer Stem Cell Phenotype in Oral Squamous Cell Carcinoma by Targeting CD24.
Sangeeta Ghuwalewala,Dishari Ghatak,Sumit Das,Stuti Roy,Pijush K. Das,Ramesh Butti,Mahadeo Gorain,Somsubhra Nath,Gopal C. Kundu,Susanta Roychoudhury +9 more
TL;DR: In this article, an elevated expression of miR-146a in the CD44highCD24low population within OSCC cells and primary HNSCC tumors was reported, which resulted in an enhanced stemness phenotype.
Posted ContentDOI
MiR-146a-dependent regulation of CD24/AKT/β-catenin axis drives cancer stem cell phenotype in oral squamous cell carcinoma
Sangeeta Ghuwalewala,Dishari Ghatak,Sumit Das,Pijush K. Das,Ramesh Butti,Mahadeo Gorain,Gopal C. Kundu,Susanta Roychoudhury +7 more
TL;DR: In this article, the authors showed that miR-146a induces stemness by stabilizing β-catenin with concomitant loss of E-cadherin and CD24.
Posted ContentDOI
MiR-146a-dependent regulation of CD24/AKT/β-catenin axis drives stem cell phenotype in oral cancer
Susanta Roychoudhury,Sangeeta Ghuwalewala,Dishari Ghatak,Sumit Das,Pijush K. Das,Ramesh Butti,Mahadeo Gorain,Gopal C. Kundu +7 more
TL;DR: This study demonstrates that miR-146a regulates CSC-driven properties in OSCC through CD24-AKT-β-catenin axis through a positive feedback loop contributing to stem cell maintenance.