Showing papers by "Sun Yeou Kim published in 2013"
TL;DR: Three new 3,6-disubstituted α-pyrones, nocapyrones H-J (1-3), were isolated from the marine actinomycete Nocardiopsis sp.
Abstract: Three new 3,6-disubstituted α-pyrones, nocapyrones H-J (1-3), were isolated from the marine actinomycete Nocardiopsis sp. KMF-001. Their structures were assigned to be 3-alkylated 6-(1-methyl-1-propenyl)-2H-pyran-2-ones on the basis of UV, MS, NMR, and high resolution (HR)-FAB-MS analyses. Nocapyrone H (1) reduced the pro-inflammatory factor such as nitric oxide (NO), prostaglandin E(2) (PGE(2)) and interleukin-1β (IL-1β). Moreover, nocapyrone H showed 5.82% stronger inhibitory effect on NO production than chrysin at a concentration of 10 µM in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells.
31 citations
TL;DR: Two new cyclic diarylheptanoids, diosniponol A and B, together with 10 known compounds were isolated from the rhizomes of Dioscorea nipponica, and showed potent inhibitory activities on NO production without cell toxicity in lipopolysaccharide-activated BV-2 cells.
23 citations
TL;DR: Evaluated H. longipes as a functional food for the treatment of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease resulted in the identification of three new steroidal compounds, longipenane, 26-O-β-d-glucopyranoside and neogitogenin.
17 citations
TL;DR: The cyclic diarylheptanoids, diosniponol A and B (I*a and B) are isolated along with ten known compounds from the rhizomes of Dioscorea nipponica.
Abstract: The cyclic diarylheptanoids, diosniponol A (I*a) and B (I*b), are isolated along with ten known compounds from the rhizomes of Dioscorea nipponica.
5 citations
TL;DR: In this paper, the isolation, structure and inhibition of NO production of three new steroidal compounds, longipenane (Ia), longipene 26-O-β-D-glucopyranoside (Ib) and trisaccharide, along with two known steroidal saponins.
Abstract: isolation, structure and inhibition of NO production of three new steroidal compounds, longipenane (Ia), longipenane 26-O-β-D-glucopyranoside (Ib) and a new trisaccharide, along with two known steroidal saponins
3 citations
TL;DR: Nocapyrone H (Ia) reduces the pro-inflammatory factor and shows stronger inhibitory effect on NO production than chrysin in lipopolysaccharide-stimulated BV-2 microglial cells.
Abstract: Nocapyrone H (Ia) reduces the pro-inflammatory factor and shows stronger inhibitory effect on NO production than chrysin in lipopolysaccharide-stimulated BV-2 microglial cells.