Sung Kwang Park

TL;DR: The observation that soluble UA alters the proliferation/migration and NO release of human vascular cells, mediated by the expression of CRP, calls for careful reconsideration of the role of UA in hypertension and vascular disease.

TL;DR: It is demonstrated that Ang1 counteracts VEGF-induced inflammation by reducing VEGf-induced endothelial adhesiveness, and reduces VEGFs' leukocyte adhesion to HUVECs.

TL;DR: By replacing the N-terminal portion of Ang1 with the short coiled-coil domain of cartilage oligomeric matrix protein (COMP), this variant is a soluble, stable, and potent Ang1 variant, COMP-Ang1, which is more potent than native Ang1 in phosphorylating the tyrosine kinase with Ig and epidermal growth factor homology domain 2 (Tie2) receptor and Akt in primary cultured endothelial cells.

TL;DR: Recombinant HFARP acts as an apoptosis survival factor for vascular endothelial cells, but does not bind to Tie1 or Tie2 (endothelial-cell tyrosine kinase receptors).

TL;DR: The study suggests that DPP IV inhibitors may ameliorate diabetic nephropathy as well as reduce the overproduction of TGF-β1.