S
Susan E. Cohen
Researcher at California State University, Los Angeles
Publications - 13
Citations - 690
Susan E. Cohen is an academic researcher from California State University, Los Angeles. The author has contributed to research in topics: DNA polymerase & Transcription (biology). The author has an hindex of 8, co-authored 11 publications receiving 609 citations. Previous affiliations of Susan E. Cohen include Massachusetts Institute of Technology.
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Journal ArticleDOI
The SOS Regulatory Network.
TL;DR: This chapter summarizes the current view of the SOS response and discusses how this genetic circuit is regulated and includes a discussion of the emergency response networks in other bacteria to provide a broader perspective on how prokaryotes respond to DNA damage.
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Y-family DNA polymerases in Escherichia coli
TL;DR: Genetic and biochemical studies have revealed that Escherichia coli genes umuC+ and its homolog dinB+ encode novel DNA polymerases with the ability to catalyze synthesis past DNA lesions that otherwise stall replication--a process termed translesion synthesis (TLS).
Journal ArticleDOI
Roles for the transcription elongation factor NusA in both DNA repair and damage tolerance pathways in Escherichia coli
Susan E. Cohen,Cindi A. Lewis,Rachel A. Mooney,Michael A. Kohanski,James J. Collins,Robert Landick,Graham C. Walker +6 more
TL;DR: Observations suggesting that the transcription elongation factor NusA promotes a previously unrecognized class of transcription-coupled repair (TCR) in addition to its previously proposed role in recruiting translesion synthesis (TLS) DNA polymerases to gaps encountered during transcription are reported.
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Transcriptional modulator NusA interacts with translesion DNA polymerases in Escherichia coli.
TL;DR: It is proposed that NusA recruits translesion DNA synthesis (TLS) polymerases to RNA polymerases stalled at gaps, coupling TLS to transcription.
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The Transcription Elongation Factor NusA Is Required for Stress-Induced Mutagenesis in Escherichia coli
Susan E. Cohen,Graham C. Walker +1 more
TL;DR: In this paper, it was shown that wild-type NusA function is required for stress-induced mutagenesis in Escherichia coli and that this effect is not due to defects in transcription of lac genes but rather is due to an inability to adapt and mutate in response to environmental stress.