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Daniel F. Jarosz
Researcher at Stanford University
Publications - 64
Citations - 5879
Daniel F. Jarosz is an academic researcher from Stanford University. The author has contributed to research in topics: Epigenetics & DNA polymerase. The author has an hindex of 30, co-authored 62 publications receiving 5240 citations. Previous affiliations of Daniel F. Jarosz include Massachusetts Institute of Technology.
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HSP90 at the hub of protein homeostasis: emerging mechanistic insights
TL;DR: Comprehensive understanding of how HSP90 functions promises not only to provide new avenues for therapeutic intervention, but to shed light on fundamental biological questions.
Prions are a common mechanism for phenotypic inheritance in wild yeasts
Randal Halfmann,Daniel F. Jarosz,Sandra K. Jones,Sandra K. Jones,Amelia N. Chang,Amelia N. Chang,Alex K. Lancaster,Susan Lindquist +7 more
TL;DR: Biochemically test approximately 700 wild strains of Saccharomyces for [PSI+] or [MOT3+], and find these prions in many, and they conferred diverse phenotypes that were frequently beneficial under selective conditions.
Journal ArticleDOI
Prions are a common mechanism for phenotypic inheritance in wild yeasts
Randal Halfmann,Daniel F. Jarosz,Sandra K. Jones,Sandra K. Jones,Amelia N. Chang,Amelia N. Chang,Alex K. Lancaster,Susan Lindquist,Susan Lindquist +8 more
TL;DR: In this paper, the self-templating conformations of yeast prion proteins act as epigenetic elements of inheritance, and they can provide a mechanism for generating heritable phenotypic diversity that promotes survival in fluctuating environments and the evolution of new traits.
Journal ArticleDOI
Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation
Daniel F. Jarosz,Susan Lindquist +1 more
TL;DR: In this article, the authors find that the nature and adaptive value of Hsp90-contingent traits remain uncertain, but they find such traits to be both common and frequently adaptive.
Journal ArticleDOI
Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish.
Nicolas Rohner,Daniel F. Jarosz,Johanna E. Kowalko,Masato Yoshizawa,William R. Jeffery,William R. Jeffery,Richard Borowsky,Susan Lindquist,Susan Lindquist,Clifford J. Tabin +9 more
TL;DR: It is suggested that cryptic variation played a role in the evolution of eye loss in cavefish and the first evidence for HSP90 as a capacitor for morphological evolution in a natural setting is provided.