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Self-assembled monolayers of thiolates on metals as a form of nanotechnology.

The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.

Nanoparticles having oligonucleotides attached thereto and uses therefor

Raman spectroscopy: Recent advancements, techniques and applications

The present invention relates to a screening methods, compositions, and kits for detecting for the presence or absence of one or more target analytes, e.g. proteins such as antibodies, in a sample. In particular, the present invention relates to a method that utilizes reporter oligonucleotides as biochemical barcodes for detecting multiple protein structures or other target analytes in one solution.

Bio-barcodes based on oligonucleotide-modified nanoparticles

Surface-enhanced Raman scattering on colloidal nanostructures

Novel hemilabile (phosphinoalkyl)arene ligands: Mechanistic investigation of an unusual intramolecular, arene-arene exchange reaction

The First Raman Spectrum of an Organic Monolayer on a High-Temperature Superconductor: Direct Spectroscopic Evidence for a Chemical Interaction between an Amine and YBa2Cu3O7-δ

Susan J. Schofer

Papers

Novel hemilabile (phosphinoalkyl)arene ligands: Mechanistic investigation of an unusual intramolecular, arene-arene exchange reaction

The First Raman Spectrum of an Organic Monolayer on a High-Temperature Superconductor: Direct Spectroscopic Evidence for a Chemical Interaction between an Amine and YBa2Cu3O7-δ