Susan M. Fisher

TL;DR: NPY induced calcium mobilization and inhibited forskolin-stimulated cAMP accumulation in Chinese hamster ovary cells that stably express the Y2 receptors cDNA, indicating that the recombinant Y2 receptor is functionally coupled to second messenger systems.

TL;DR: Bacillaene, a novel polyene antibiotic, was discovered and isolated from fermentation broths of a strain of Bacillus subtilis and indicates that the antibiotic is a bacteriostatic agent.

TL;DR: Estimation of the wild-type and mutant ETA receptors in COS-7 cells revealed that the binding profile of one of the ETA mutants, Tyr129-->Ala, was characteristic of the ETB receptor, and these data represent the first example of peptide interactions with a transmembrane region of a G protein-coupled receptor and indicate that Tyr129 is a critical component for determination of endothelin receptor subtype-selective ligand binding.

TL;DR: The isolation, by low stringency homology cloning from a hypothalamic library, of a cDNA encoding the human homolog of the murine neuropeptide Y receptor is reported, indicating that this receptor subtype may be a transcribed pseudogene in humans.

TL;DR: Data support the hypothesis that Asp126 and Asp133 flanking Tyr129 in TM2 of the ETA receptor play a role in defining ETA subtype‐selective ligand binding but Asp147 and AsP154 that flank the His150 in TM 2 of the ETB receptor do not.