S
Susan M. Ludeman
Researcher at Albany College of Pharmacy and Health Sciences
Publications - 33
Citations - 1998
Susan M. Ludeman is an academic researcher from Albany College of Pharmacy and Health Sciences. The author has contributed to research in topics: Phosphoramide Mustard & Alkyltransferase. The author has an hindex of 18, co-authored 33 publications receiving 1904 citations. Previous affiliations of Susan M. Ludeman include University of Chicago & KAIST.
Papers
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Journal ArticleDOI
Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity.
Robert W. Storms,A P Trujillo,J B Springer,L Shah,O M Colvin,Susan M. Ludeman,Clayton A. Smith +6 more
TL;DR: Observations indicate that fractionating human hematopoietic stem cells on the basis of aldehyde dehydrogenase activity using BAAA is an effective method for isolating primitive humanHematopOietic progenitors from other tissues as well.
Journal ArticleDOI
Evaluation of an elastin-like polypeptide-doxorubicin conjugate for cancer therapy
Matthew R. Dreher,Drazen Raucher,Narayanan Balu,O. Michael Colvin,Susan M. Ludeman,Ashutosh Chilkoti +5 more
TL;DR: Interestingly, both the ELP-dox conjugate and free drug exhibited near equivalent in vitro cytotoxicity, although their subcellular localization was significantly different.
Journal Article
The chemistry of the metabolites of cyclophosphamide.
TL;DR: An overview of the spontaneous chemistry of cyclophosphamide metabolites can be found in this paper, where perturbations to metabolite distributions and half-lives effected by buffer, structure, pH and nucleophiles are discussed.
Journal ArticleDOI
The Chemistry of the Metabolites of Cyclophosphamide
TL;DR: Among the topics covered are: perturbations to metabolite distributions and half-lives effected by buffer, structure, pH and nucleophiles; effects of pH on mechanism; alkylation versus P-N bond hydrolysis; the influence ofucleophiles on alkylated product distributions; and preactivated forms of cyclophosphamide as metabolite precursors (4-hydroperoxycycloph phosphamide and mafosfamide).
Journal Article
Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents.
Henry S. Friedman,Colvin Om,Stephen X. Skapek,Susan M. Ludeman,Gertrude B. Elion,S. C. Schold,P. F. Jacobsen,Lawrence H. Muhlbaier,Darell D. Bigner +8 more
TL;DR: The results extend the previous studies demonstrating the antitumor activity of nitrogen and phosphoramide mustard-based bifunctional alkylating agents in the treatment of human medulloblastoma continuous cell lines and transplantable xenografts, and support the continued use of these agents in clinical trials.