Susanne Rössner

TL;DR: This method allows by simple means the generation of high numbers of murine DC with very low B cell or granulocyte contaminations, which will be valuable to study DC biology notably at the molecular level.

TL;DR: These maturation‐resistant immature GMlo DC induced T cell unresponsiveness in vitro and in vivo and may have important implications for future studies in T cell tolerance induction in vivo.

TL;DR: The generation of MSC is described as myeloid DC precursors with potent suppressive activity on allogeneic and OVA‐specific CD4+ and CD8+ T cell responses in vitro preceding their development into immature DC.

TL;DR: IL-4 and IL-13 are able to promote DC maturation, as evaluated by up-regulation of MHC class II and costimulatory molecules, when the concentration of GM-CSF is relatively lower than the dose of IL-4 or IL- 13, and under these conditions both cytokines enable DC to respond to maturation stimuli such as bacterial products or proinflammatory cytokines.

TL;DR: It is shown that TNF/DC are not terminally differentiated but can still respond to the microbial stimulus lipopolysaccharide, which is important for selecting the appropriate injection route of human DC for tumor immunotherapy.