S
Sven Heldt
Researcher at Medical University of Graz
Publications - 11
Citations - 366
Sven Heldt is an academic researcher from Medical University of Graz. The author has contributed to research in topics: Bronchoalveolar lavage & Aspergillosis. The author has an hindex of 7, co-authored 10 publications receiving 298 citations.
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Journal ArticleDOI
Galactomannan testing and Aspergillus PCR in same-day bronchoalveolar lavage and blood samples for diagnosis of invasive aspergillosis.
Susanne Eigl,Martin Hoenigl,Birgit Spiess,Sven Heldt,Juergen Prattes,Peter Neumeister,Albert Wölfler,Jasmin Rabensteiner,Florian Prueller,Robert Krause,Mark Reinwald,Holger Flick,Dieter Buchheidt,Tobias Boch +13 more
TL;DR: In conclusion, sensitivities of the evaluated diagnostic tests—when interpreted on their own—were low in BALF and even lower in blood, but sensitivities increased markedly when diagnostic tests were combined.
Journal ArticleDOI
Diagnosis of invasive aspergillosis in hematological malignancy patients: Performance of cytokines, Asp LFD, and Aspergillus PCR in same day blood and bronchoalveolar lavage samples.
Sven Heldt,Juergen Prattes,Susanne Eigl,Birgit Spiess,Holger Flick,Jasmin Rabensteiner,Gemma L Johnson,Florian Prüller,Albert Wölfler,Tobias Niedrist,Tobias Boch,Peter Neumeister,Heimo Strohmaier,Robert Krause,Dieter Buchheidt,Martin Hoenigl +15 more
TL;DR: High serum IL-8 levels were highly specific, and when combined with either the BALF Aspergillus-specific LFD, or BALF PCR also highly sensitive for diagnosis of IA, which was the most reliable blood biomarker.
Journal ArticleDOI
Clinical evaluation of the newly formatted lateral-flow device for invasive pulmonary aspergillosis.
Martin Hoenigl,Susanne Eigl,Sven Heldt,Wiebke Duettmann,Christopher R. Thornton,Juergen Prattes +5 more
TL;DR: The study evaluated the newly formatted Aspergillus‐specific lateral‐flow‐device (LFD) and compared its performance to the original prototype “old” LFD test using BALF samples from 28 patients, finding specificity of the new LFD was significantly improved compared to the old LFD.
Journal ArticleDOI
Lateral Flow Assays for the Diagnosis of Invasive Aspergillosis: Current Status.
TL;DR: An update is given on the Aspergillus-specific lateral-flow device (LFD) test, which is based on the JF5 antibody (Ab) and has shown promising results in various studies, and the search for reliable POC tests for other molds continues.
Journal ArticleDOI
Levels of interleukin (IL)‐6 and IL‐8 are elevated in serum and bronchoalveolar lavage fluid of haematological patients with invasive pulmonary aspergillosis
Sven Heldt,Susanne Eigl,Juergen Prattes,Holger Flick,Jasmin Rabensteiner,Florian Prüller,Tobias Niedrist,Peter Neumeister,Albert Wölfler,Heimo Strohmaier,Robert Krause,Martin Hoenigl +11 more
TL;DR: Levels of IL‐6 and IL‐8 were significantly associated with probable/proven IPA, and a similar trend was observed for serum IL‐10, and future cohort studies should determine the diagnostic potential of these cytokines for IPA.