Swen Hesse

TL;DR: It appears that low NAT availability is associated with greater scores of impaired behavioral control, but this needs to be confirmed in a larger series of individuals with highly impulsive behavior.

TL;DR: The results indicate that regulative temperament – particularly the capacity to mitigate negatively toned impulses and to resist inappropriate avoidance behavior – might be associated with the prefrontal serotonergic system.

TL;DR: It is shown that central in vivo NET availability is altered in EE of individuals with obesity, and correlative data analyses pointed to a sinoidal distribution pattern as a higher degree of EE related to lower NET availability in the locus coeruleus and to higher NET available in the left thalamus.

TL;DR: Positive correlations were found between the NAT distribution volume ratios (DVR) of the orbitofrontal cortex and the amygdala with the HPA response in non-obese controls and in obesity, which suggests a mechanistic interaction between noradrenergic transmission with HPA axis activity and the serum AVP system that differs between non-OBese individuals with prefrontal-limbic involvement and obesity with a hypothalamic-centered relationship.

TL;DR: The metabolic study, in particular the high fractions of unchanged radioligand in plasma, confirms the suitability of (S)-[18F]1 as PET radiolIGand for sigma-1 receptor imaging.