S
Swen Hesse
Researcher at Leipzig University
Publications - 164
Citations - 3971
Swen Hesse is an academic researcher from Leipzig University. The author has contributed to research in topics: Serotonin transporter & Dopaminergic. The author has an hindex of 34, co-authored 151 publications receiving 3367 citations. Previous affiliations of Swen Hesse include Hannover Medical School.
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Journal ArticleDOI
Decreased cerebral α4β2* nicotinic acetylcholine receptor availability in patients with mild cognitive impairment and Alzheimer’s disease assessed with positron emission tomography
Kai Kendziorra,Henrike Wolf,Henrike Wolf,Philipp Meyer,Henryk Barthel,Swen Hesse,Georg Becker,Julia Luthardt,Andreas Schildan,Marianne Patt,Dietlind Sorger,Anita Seese,Herman-Josef Gertz,Osama Sabri +13 more
TL;DR: 2-[18F]FA-85380 PET appears to be a sensitive and feasible tool for the detection of a reduction in α4β2* nAChRs which seems to be an early event in AD.
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Individualized quantification of brain β-amyloid burden: results of a proof of mechanism phase 0 florbetaben PET trial in patients with Alzheimer's disease and healthy controls.
Henryk Barthel,Julia Luthardt,Georg Becker,Marianne Patt,Eva Hammerstein,Kristin Hartwig,Birk Eggers,Bernhard Sattler,Andreas Schildan,Swen Hesse,Philipp Meyer,Henrike Wolf,Henrike Wolf,Torsten Zimmermann,Joachim Reischl,Beate Rohde,Hermann-Josef Gertz,Cornelia Reininger,Osama Sabri +18 more
TL;DR: Results indicate florbetaben to be a safe and efficacious β-amyloid-targeted tracer with favourable brain kinetics, which appeared valuable as a surrogate marker of disease severity.
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Gastric Bypass Surgery Recruits a Gut PPAR-α-Striatal D1R Pathway to Reduce Fat Appetite in Obese Rats
Mohammed K. Hankir,Florian Seyfried,Constantin Hintschich,Thi-Ai Diep,Karen Kleberg,Mathias Kranz,Winnie Deuther-Conrad,Luis A. Tellez,Michael Rullmann,Marianne Patt,Jens Teichert,Swen Hesse,Osama Sabri,Peter Brust,Harald S. Hansen,Ivan E. de Araujo,Ute Krügel,Wiebke Fenske +17 more
TL;DR: A molecular/systems pathway through which bariatric surgery improves feeding behavior is delineated and may aid in the development of novel weight loss strategies that similarly modify brain reward circuits compromised in obesity.
Journal ArticleDOI
Reduced serotonin transporter-availability in obsessive-compulsive disorder (OCD).
TL;DR: In vivo finding of significant reduced serotonin transporter availability in midbrain/brainstem using [123I] β–CIT SPECT further supports the serotonin deficit hypothesis of OCD.
Journal ArticleDOI
Monoamine transporter availability in Parkinson's disease patients with or without depression
Swen Hesse,Philipp Meyer,Karl Strecker,Henryk Barthel,Florian Wegner,Christian Oehlwein,Ioannis U. Isaias,Johannes Schwarz,Osama Sabri +8 more
TL;DR: In vivo data indicate that depression in PD is associated with a more pronounced loss of striatal dopamine transporter availability that is most likely secondary to increased dopaminergic degeneration, and depressed PD patients have a lower availability of midbrain/brainstem monoamine transporters than nondepressed PD patients.