S
Sylvain Julien
Researcher at university of lille
Publications - 40
Citations - 3110
Sylvain Julien is an academic researcher from university of lille. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 25, co-authored 40 publications receiving 2785 citations. Previous affiliations of Sylvain Julien include French Institute of Health and Medical Research & University of the Sciences.
Papers
More filters
Journal ArticleDOI
The human sialyltransferase family
Anne Harduin-Lepers,Verónica Vallejo-Ruiz,Marie-Ange Krzewinski-Recchi,Bénédicte Samyn-Petit,Sylvain Julien,Philippe Delannoy +5 more
TL;DR: An overview of the 15 different human sialyltransferase cDNAs, the regulation of their occurrence and their involvement in several physiological and pathological processes is presented.
Journal ArticleDOI
Retargeting of human T cells to tumor-associated MUC1: the evolution of a chimeric antigen receptor.
Scott Wilkie,Gianfranco Picco,Julie Foster,David M. Davies,Sylvain Julien,Lucienne Cooper,Sefina Arif,Stephen J. Mather,Joyce Taylor-Papadimitriou,Joy Burchell,John Maher +10 more
TL;DR: Together, these data demonstrate for the first time that the near-ubiquitous MUC1 tumor Ag can be targeted using CAR-grafted T cells.
Journal ArticleDOI
Tumour-associated carbohydrate antigens in breast cancer
Aurélie Cazet,Aurélie Cazet,Sylvain Julien,Marie Bobowski,Marie Bobowski,Joy Burchell,Philippe Delannoy,Philippe Delannoy +7 more
TL;DR: The present review summarizes the current knowledge of glycosylation changes (structures, biosynthesis and occurrence) in breast cancer cell lines and primary tumours, and the consequences on disease progression and aggressiveness.
Journal ArticleDOI
ST6GalNAc I expression in MDA-MB-231 breast cancer cells greatly modifies their O-glycosylation pattern and enhances their tumourigenicity.
Sylvain Julien,Eric Adriaenssens,K. Ottenberg,Alessandro Furlan,G. Courtand,Anne-Sophie Vercoutter-Edouart,Franz-Georg Hanisch,Philippe Delannoy,X. Le Bourhis +8 more
TL;DR: Modifications of the O-glycosylation pattern of a MUC1-related recombinant protein secreted by MDA-MB-231 sialyl-Tn positive cells are reported here to enhance the tumourigenicity of Mda- MB-231 breast cancer cells.
Journal ArticleDOI
Autoantibodies to aberrantly glycosylated MUC1 in early stage breast cancer are associated with a better prognosis
Ola Blixt,Deanna Bueti,Brian Burford,Brian Burford,Diane Allen,Sylvain Julien,Michael A. Hollingsworth,Alexander Gammerman,Ian S. Fentiman,Joyce Taylor-Papadimitriou,Joy Burchell +10 more
TL;DR: Autoantibodies to specific cancer associated glycoforms of MUC1 are found more frequently and at higher levels in early stage breast cancer patients than in women with benign breast disease or healthy women.