S
Sylvain Lengacher
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 25
Citations - 2967
Sylvain Lengacher is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Astrocyte & Glutamate receptor. The author has an hindex of 17, co-authored 24 publications receiving 2396 citations. Previous affiliations of Sylvain Lengacher include MIND Institute & University of Lausanne.
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Journal ArticleDOI
Oligodendroglia metabolically support axons and contribute to neurodegeneration
Youngjin Lee,Brett M. Morrison,Yun Li,Sylvain Lengacher,Mohamed H. Farah,Paul N. Hoffman,Yiting Liu,Akivaga Tsingalia,Lin Jin,Ping Wu Zhang,Luc Pellerin,Pierre J. Magistretti,Jeffrey D. Rothstein +12 more
TL;DR: It is shown that the most abundant lactate transporter in the central nervous system, monocarboxylate transporter 1 (MCT1, also known as SLC16A1), is highly enriched within oligodendroglia and that disruption of this transporter produces axon damage and neuron loss in animal and cell culture models.
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In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons
Philipp Mächler,Matthias T. Wyss,Maha Elsayed,Jillian L. Stobart,Robin Gutiérrez,Robin Gutiérrez,Alexandra von Faber-Castell,Vincens Kaelin,Marc Zuend,Alejandro San Martín,Ignacio Romero-Gómez,Felipe Baeza-Lehnert,Sylvain Lengacher,Bernard L. Schneider,Patrick Aebischer,Pierre J. Magistretti,Pierre J. Magistretti,L. Felipe Barros,Bruno Weber +18 more
TL;DR: In vivo evidence for a lactate gradient is a prerequisite for a carrier-mediated lactate flux from astrocytes to neurons and thus supports theAstrocyte-neuron lactate shuttle model, in which astroCyte-derived lactate acts as an energy substrate for neurons.
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Channel-mediated lactate release by K⁺-stimulated astrocytes.
Tamara Sotelo-Hitschfeld,María Isabel Niemeyer,Philipp Mächler,Iván Ruminot,Rodrigo Lerchundi,Matthias T. Wyss,Jillian L. Stobart,Ignacio Fernández-Moncada,Rocío Valdebenito,Pamela Garrido-Gerter,Yasna Contreras-Baeza,Bernard L. Schneider,Patrick Aebischer,Sylvain Lengacher,Alejandro San Martín,Juliette Le Douce,Gilles Bonvento,Pierre J. Magistretti,Francisco V. Sepúlveda,Bruno Weber,L. Felipe Barros +20 more
TL;DR: It is shown that mouse astrocytes in culture, in cortical slices, and in vivo maintain a steady-state reservoir of lactate, and its quick mobilization via an ion channel in response to a neuronal cue provides fresh support to lactate roles in neuronal fueling and in gliotransmission.
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Astrocytic β2-adrenergic receptors mediate hippocampal long-term memory consolidation.
Virginia Gao,Virginia Gao,Akinobu Suzuki,Pierre J. Magistretti,Pierre J. Magistretti,Sylvain Lengacher,Sylvain Lengacher,Gabriella Pollonini,Michael Q. Steinman,Cristina M. Alberini +9 more
TL;DR: It is shown that astrocytic rather than neuronal β2ARs in the hippocampus play a key role in the consolidation of a fear-based contextual memory, which may represent a novel target mechanism for stress-related psychopathologies and neurodegeneration.
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Cell-specific expression pattern of monocarboxylate transporters in astrocytes and neurons observed in different mouse brain cortical cell cultures
TL;DR: An extensive description of MCT distribution in cultured cells is provided, to underscore the potential of such preparations for future studies on the regulation of M CT expression.