F
Francisco V. Sepúlveda
Researcher at Centro de Estudios Científicos
Publications - 121
Citations - 4883
Francisco V. Sepúlveda is an academic researcher from Centro de Estudios Científicos. The author has contributed to research in topics: Chloride channel & Gating. The author has an hindex of 37, co-authored 119 publications receiving 4674 citations. Previous affiliations of Francisco V. Sepúlveda include University of Chile.
Papers
More filters
Journal ArticleDOI
Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein.
Miguel A. Valverde,Mario Díaz,Francisco V. Sepúlveda,Deborah R. Gill,Stephen C. Hyde,Christopher F. Higgins +5 more
TL;DR: It is reported here that expression of P-glycoprotein generates volume-regulated, ATP-dependent, chloride-selective channels, with properties similar to channels characterized previously in epithelial cells.
Journal ArticleDOI
Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein.
Deborah R. Gill,Stephen C. Hyde,Christopher F. Higgins,Miguel A. Valverde,G. M. Mintenig,Francisco V. Sepúlveda +5 more
TL;DR: Data provided provide further evidence that P-glycoprotein is bifunctional with both transport and channel activities and implications for the design of chemotherapeutic drugs and for the function of the related cystic fibrosis gene product, CFTR are discussed.
Journal ArticleDOI
The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression.
Ann E. O. Trezise,P. R. Romano,Deborah R. Gill,Stephen C. Hyde,Francisco V. Sepúlveda,M. Buchwald,Christopher F. Higgins +6 more
TL;DR: The patterns of expression suggest that the regulation of these two genes is coordinately controlled and provide additional evidence that P‐glycoprotein has a physiological role in regulating epithelial cell volume.
Journal ArticleDOI
Tamoxifen blocks chloride channels. A possible mechanism for cataract formation.
Jin Jun Zhang,Timothy John Claud Jacob,Miguel A. Valverde,Simon P. Hardy,G. M. Mintenig,Francisco V. Sepúlveda,Deborah R. Gill,Stephen C. Hyde,A E Trezise,Christopher F. Higgins +9 more
TL;DR: A molecular mechanism by which tamoxifen can cause cataract formation is suggested and implications for the clinical use of tamoxIFen and related antiestrogens are suggested.
Journal ArticleDOI
Channel-mediated lactate release by K⁺-stimulated astrocytes.
Tamara Sotelo-Hitschfeld,María Isabel Niemeyer,Philipp Mächler,Iván Ruminot,Rodrigo Lerchundi,Matthias T. Wyss,Jillian L. Stobart,Ignacio Fernández-Moncada,Rocío Valdebenito,Pamela Garrido-Gerter,Yasna Contreras-Baeza,Bernard L. Schneider,Patrick Aebischer,Sylvain Lengacher,Alejandro San Martín,Juliette Le Douce,Gilles Bonvento,Pierre J. Magistretti,Francisco V. Sepúlveda,Bruno Weber,L. Felipe Barros +20 more
TL;DR: It is shown that mouse astrocytes in culture, in cortical slices, and in vivo maintain a steady-state reservoir of lactate, and its quick mobilization via an ion channel in response to a neuronal cue provides fresh support to lactate roles in neuronal fueling and in gliotransmission.