Y
Youngjin Lee
Researcher at City University of Hong Kong
Publications - 31
Citations - 2639
Youngjin Lee is an academic researcher from City University of Hong Kong. The author has contributed to research in topics: Medicine & Glial fibrillary acidic protein. The author has an hindex of 14, co-authored 25 publications receiving 2006 citations. Previous affiliations of Youngjin Lee include Johns Hopkins University School of Medicine & Johns Hopkins University.
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Journal ArticleDOI
Oligodendroglia metabolically support axons and contribute to neurodegeneration
Youngjin Lee,Brett M. Morrison,Yun Li,Sylvain Lengacher,Mohamed H. Farah,Paul N. Hoffman,Yiting Liu,Akivaga Tsingalia,Lin Jin,Ping Wu Zhang,Luc Pellerin,Pierre J. Magistretti,Jeffrey D. Rothstein +12 more
TL;DR: It is shown that the most abundant lactate transporter in the central nervous system, monocarboxylate transporter 1 (MCT1, also known as SLC16A1), is highly enriched within oligodendroglia and that disruption of this transporter produces axon damage and neuron loss in animal and cell culture models.
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GFAP promoter elements required for region‐specific and astrocyte‐specific expression
TL;DR: The heterogeneity of astrocytes and neurons in the activation and repression of the GFAP gene is confirmed, and a novel 681 bp GFAP promoter, gfaABC1D, is generated that has essentially the same expression pattern as the 2210 bp gfa2 promoter, and about twofold greater activity.
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Oligodendroglia: metabolic supporters of axons.
TL;DR: Evidence for the vulnerability of neurons to energy deprivation, the importance of oligodendrocytes for axon function and survival, and recent data suggesting that transfer of energy metabolites from oligodendedroglia to axons through monocarboxylate transporter 1 (MCT1) may be critical for the survival of axons are discussed.
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Direct detection of two different tumor-derived extracellular vesicles by SAM-AuNIs LSPR biosensor.
Abhimanyu Thakur,Guangyu Qiu,Siu-Pang Ng,Jintao Guan,Jianbo Yue,Youngjin Lee,Chi-Man Lawrence Wu +6 more
TL;DR: It is reported for the first time that the in-house developed Localized Surface Plasmon Resonance biosensor with self-assembly gold nanoislands (SAM-AuNIs) can be used to detect and distinguish exosomes from MVs isolated from A-549 cells, SH-SY5Y cells, blood serum, and urine from a lung cancer mouse model.
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Expression Specificity of GFAP Transgenes
TL;DR: It is demonstrated here that these DNA sequences can also direct activity in neurons and that neuronal expression was very high for a protective protein/cathepsin A minigene, moderate for lacZ and undetectable for GFP.