Sylvette Hoffstetter

TL;DR: In this paper, a prospective study of 174 patients treated for medulloblastoma was conducted to correlate targeting deviation in external beam radiation therapy with site of relapse, and the authors found that minor deviations in therapy technique are slightly associated with an increased risk of relapse in the same range as the group with only one major deviation.

TL;DR: Results suggest that patients with standard-risk disease could be treated with radiochemotherapy, reducing doses to the craniospinal area, maintaining at least 50 Gy to the PCF, similar to those observed in children.

TL;DR: The confirmation of pretherapeutic prognostic factors related to response to the treatment should allow us to adapt the therapeutic intensity for each case to obtain better tumor control, with as few sequelae as possible, to yield a better rate of SC.

TL;DR: This hyperfractionated radiotherapy protocol with a reduced boost volume and without chemotherapy was not associated with early relapses in children, and intellectual function seemed to be preserved, which is promising.