/pdf/pathology-and-genetics-of-tumours-of-the-digestive-system-3xy9cwrc3c.pdf

Pathology and genetics of tumours of the digestive system

Ductal carcinoma in situ (DCIS) of the breast represents a heterogeneous group of neoplastic lesions in the breast ducts. The goal for management of DCIS is to prevent the development of invasive breast cancer. This manuscript focuses on the NCCN Guidelines Panel recommendations for the workup, primary treatment, risk reduction strategies, and surveillance specific to DCIS.

https://www.unitypoint.org/desmoines/filesimages/Cancer%20Education/Oncology%20Nursing%20Conference/2015/2014%20NCCN%20Clin%20Pract%20Guidelines%20Male%20Sex%20Dysf.pdf

Clinical practice guidelines in oncology

As survival among children treated for cancer continues to improve, more attention is being focussed on the late effects of cancer treatment. In children treated for brain tumours, chronic neurocognitive effects are especially challenging. Deficits in cognitive development have been described most thoroughly among children treated for posterior-fossa tumours, specifically medulloblastomas and ependymomas, which account for about 30% of all newly diagnosed cases of brain tumours in children. Most children who have survived brain tumours have required surgical resection and focal or craniospinal radiotherapy (irradiation of the entire subarachnoid volume of the brain and spine), with or without systemic chemotherapy. Historically, intelligence quotient (IQ) scores have provided a benchmark against which to measure changes in cognitive development after treatment. Observed declines in IQ are most likely a result of failure to learn at a rate that is appropriate for the age of the child, rather than from a loss of previously acquired knowledge. The rate of IQ decline is associated with a several risk factors, including younger age at time of treatment, longer time since treatment, female sex, as well as clinical variables such as hydrocephalus, use of radiotherapy and radiotherapy dose, and the volume of the brain that received treatment. Loss of cerebral white matter and failure to develop white matter at a rate appropriate to the developmental stage of the child could partly account for changes in IQ score. Technical advances in radiotherapy hold promise for lowering the frequency of neurocognitive sequelae. Further efforts to limit neurocognitive sequelae have included design of clinical trials to test the effectiveness of cognitive, behavioural, and pharmacological interventions.

Late neurocognitive sequelae in survivors of brain tumours in childhood.

Treatment of Non-Metastatic Muscle-Invasive Bladder Cancer: AUA/ASCO/ASTRO/SUO Guideline.

Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

Quality assurance of a French multicentric conformal radiotherapy protocol for low-stage medulloblastoma : variability in target volume delineation

Curved angiocatheter metal guide for the implantation in velo-tonsillar carcinomas.

L'irradiation postoperatoire des cicatrices cheloides permet de reduire de moitie le taux de recidive par rapport a une chirurgie d'exerese isolee. Une revue de la litterature illustre les benefices de l'irradiation, ainsi que les methodes d'irradiation possibles. La technique de curietherapie interstitielle par Iridium 192, avec mise en place per-operatoire, et irradiation precoce delivrant 20 Gy a 5 mm de profondeur est decrite telle qu'elle est utilisee par les equipes francaises et nous-memes. L'analyse des resultats publies permet de recommander l'utilisation de cette technique d'irradiation postoperatoire immediate, la mieux adaptee a chaque situation clinique, sans danger et peu contraignante pour le chirurgien

Sylvette Hoffstetter

Papers

Quality assurance of a French multicentric conformal radiotherapy protocol for low-stage medulloblastoma : variability in target volume delineation

Curved angiocatheter metal guide for the implantation in velo-tonsillar carcinomas.

Surgery and curietherapy of keloids

Impact of targeting deviations on outcome in medulloblastoma. Update of the french medulloblastoma study group (French society of pediatric oncology)

Multivariate Analysis of Prognostic Factors in Adult Medulloblastoma: Retrospective Multicentric Study