S
Sylvie Daulouède
Researcher at University of Bordeaux
Publications - 27
Citations - 1422
Sylvie Daulouède is an academic researcher from University of Bordeaux. The author has contributed to research in topics: Trypanosoma brucei & Arginase. The author has an hindex of 17, co-authored 27 publications receiving 1335 citations. Previous affiliations of Sylvie Daulouède include Centre national de la recherche scientifique & Université Bordeaux Segalen.
Papers
More filters
Journal ArticleDOI
l-Arginine Availability Modulates Local Nitric Oxide Production and Parasite Killing in Experimental Trypanosomiasis
Alain P. Gobert,Alain P. Gobert,Sylvie Daulouède,Michel Lepoivre,Jean Luc Boucher,Bernard Bouteille,Alain Buguet,Raymond Cespuglio,Bernard Veyret,Philippe Vincendeau +9 more
TL;DR: The role of l-arginine depletion, induced by arginase and parasites, in modulating the l- arginine–NO pathway under pathophysiological conditions is indicated.
Journal ArticleDOI
Nitric oxide-mediated cytostatic activity on Trypanosoma brucei gambiense and Trypanosoma brucei brucei.
P. Vincendeau,Sylvie Daulouède,Bernard Veyret,Marie Laure Dardé,Bernard Bouteille,Jean Loup Lemesre +5 more
TL;DR: The data show that activated macrophages exert an antimicrobial effect on T.b. gambiense and T. brucei through the L-arginine-NO metabolic pathway, indicating a role for NO as the effector molecule in trypanosomes.
Journal ArticleDOI
Arginases in parasitic diseases.
TL;DR: It is proposed that a common mechanism whereby different parasites escape nitric oxide (NO) toxicity is the activation of arginase, which leads to a depletion of l-arginine and increased production of polyamines, necessary for parasite growth and differentiation.
Journal ArticleDOI
Nitric Oxide-Mediated Proteasome-Dependent Oligonucleosomal DNA Fragmentation in Leishmania amazonensis Amastigotes
Philippe Holzmuller,Denis Sereno,Mireille Cavaleyra,Isabelle Mangot,Sylvie Daulouède,Philippe Vincendeau,Jean-Loup Lemesre +6 more
TL;DR: No-induced oligonucleosomal DNA fragmentation in Leishmania amastigotes is, at least in part, regulated by noncaspase proteases of the proteasome, suggesting the determination of biochemical pathways leading up to cell death might ultimately allow the identification of new therapeutic targets.
Journal ArticleDOI
Revisiting the central metabolism of the bloodstream forms of Trypanosoma brucei: production of acetate in the mitochondrion is essential for parasite viability.
Muriel Mazet,Pauline Morand,Marc Biran,Guillaume Bouyssou,Pierrette Courtois,Sylvie Daulouède,Yoann Millerioux,Jean-Michel Franconi,Philippe Vincendeau,Patrick Moreau,Frédéric Bringaud +10 more
TL;DR: It is shown that mitochondrial production of acetate is essential for the long-slender forms of T. brucei to feed the essential fatty acid biosynthesis through the “acetate shuttle” that was recently described in the procyclic insect form of the parasite.