M
Michel Lepoivre
Researcher at Centre national de la recherche scientifique
Publications - 42
Citations - 3007
Michel Lepoivre is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Ribonucleotide reductase & Nitric oxide. The author has an hindex of 20, co-authored 40 publications receiving 2927 citations. Previous affiliations of Michel Lepoivre include University of Rennes & Joseph Fourier University.
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Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
TL;DR: It is shown that Resveratrol is a remarkable inhibitor of ribonucleotide reductase and DNA synthesis in mammalian cells, which might have further applications as an antiproliferative or a cancer chemopreventive agent in humans.
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EPR characterization of molecular targets for NO in mammalian cells and organelles.
TL;DR: How electron paramagnetic resonance spectroscopy helps to detect unambiguously such specific molecular targets for NO in mammalian whole cells and organelles is reviewed.
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Inactivation of ribonucleotide reductase by nitric oxide.
TL;DR: Nitric oxide generated from sodium nitroprusside, S-nitrosoglutathione and the sydnonimine SIN-1 inhibits ribonucleotide reductase activity present in cytosolic extracts of TA3 mammary tumor cells.
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Alterations of ribonucleotide reductase activity following induction of the nitrite-generating pathway in adenocarcinoma cells.
TL;DR: It is demonstrated that, in an acellular preparation, molecules derived from the NO2(-)-generating pathway exert an inhibitory effect on the ribonucleotide reductase enzyme.
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l-Arginine Availability Modulates Local Nitric Oxide Production and Parasite Killing in Experimental Trypanosomiasis
Alain P. Gobert,Alain P. Gobert,Sylvie Daulouède,Michel Lepoivre,Jean Luc Boucher,Bernard Bouteille,Alain Buguet,Raymond Cespuglio,Bernard Veyret,Philippe Vincendeau +9 more
TL;DR: The role of l-arginine depletion, induced by arginase and parasites, in modulating the l- arginine–NO pathway under pathophysiological conditions is indicated.