S
Szabolcs Lehel
Researcher at Copenhagen University Hospital
Publications - 54
Citations - 1344
Szabolcs Lehel is an academic researcher from Copenhagen University Hospital. The author has contributed to research in topics: Radioligand & Serotonin transporter. The author has an hindex of 17, co-authored 52 publications receiving 1118 citations. Previous affiliations of Szabolcs Lehel include University of Copenhagen.
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Journal ArticleDOI
18F-Labelling of electron rich iodonium ylides: application to the radiosynthesis of potential 5-HT2A receptor PET ligands
Ida Nymann Petersen,Jonas Villadsen,Hanne D. Hansen,Joseph R. Madsen,Anders A. Jensen,Nic Gillings,Szabolcs Lehel,Matthias M. Herth,Gitte M. Knudsen,Jesper L. Kristensen +9 more
TL;DR: Subsequent evaluation in pigs showed high brain uptake of the PET ligands but a blocking dose of ketanserin did not significantly reduce the signal in relevant brain regions - indicating that the ligands do not interact specifically with the 5-HT2A receptor in vivo.
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Convergent 18F-labeling and evaluation of N-benzyl-phenethylamines as 5-HT2A receptor PET ligands.
Ida Nymann Petersen,Jonas Villadsen,Hanne D. Hansen,Anders A. Jensen,Szabolcs Lehel,Nic Gillings,Matthias M. Herth,Gitte M. Knudsen,Jesper L. Kristensen +8 more
TL;DR: A convergent radiochemical approach is developed giving easy access to 5 different 18F-labeled ligands structurally related to Cimbi-36 from a common 18F -labeled intermediate, which seems unsuitable for neuroimaging of the 5-HT2AR in vivo.
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HPLC methods for the purification of [11C]-labelled radiopharmaceuticals: reversal of the retention order of products and precursors
TL;DR: By using ethanol as the organic modifier, residual solvent analysis prior to human injection could be avoided and three of the radiopharmaceuticals could be injected directly following simple dilution and sterile filtration.
Journal ArticleDOI
Labeling and preliminary in vivo evaluation of the 5-HT7 receptor selective agonist [11C]E-55888
Hanne D. Hansen,Valdemar L. Andersen,Szabolcs Lehel,Janus H. Magnussen,Agnete Dyssegaard,Nikolas Stroth,Jesper L. Kristensen,Gitte M. Knudsen,Matthias M. Herth +8 more
TL;DR: The synthesis, radiolabeling and in vivo evaluation of [(11)C]E-55888 as a radioligand for positron emission tomography (PET) imaging shows promise, but the distribution in the brain tissue was dominated by non-specific binding.
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Migraine is associated with high brain 5-HT levels as indexed by 5-HT4 receptor binding.
Marie Deen,Anders Hougaard,Hanne D. Hansen,Claus Svarer,Hans Eiberg,Szabolcs Lehel,Gitte M. Knudsen,Messoud Ashina +7 more
TL;DR: Elevated brain 5-HT levels may be an inherent trait of the migraine brain rather than a risk factor for conversion from episodic to chronic migraine.