T
Tabitha Black
Researcher at Amgen
Publications - 2
Citations - 1781
Tabitha Black is an academic researcher from Amgen. The author has contributed to research in topics: Vascular endothelial growth factor C & Endothelial stem cell. The author has an hindex of 2, co-authored 2 publications receiving 1727 citations.
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Journal ArticleDOI
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
Hailing Hsu,David L. Lacey,Colin R. Dunstan,Irina Solovyev,Anne Colombero,Emma Timms,Hong-Lin Tan,Gary Elliott,Michael J. Kelley,Ildiko Sarosi,Ling Wang,Xing-Zhong Xia,Robin Elliott,Laura Chiu,Tabitha Black,Sheila Scully,Casey Capparelli,Sean Morony,Grant Shimamoto,Michael Bass,William J. Boyle +20 more
TL;DR: Data indicate that OPGL-induced osteoclastogenesis is directly mediated through RANK on osteocLast precursor cells, and polyclonal Ab against the RANK extracellular domain promotes osteoclineogenesis in bone marrow cultures suggesting that RANK activation mediates the effects of OPGl on the osteoc last pathway.
Journal ArticleDOI
Inflammatory cytokines and vascular endothelial growth factor stimulate the release of soluble tie receptor from human endothelial cells via metalloprotease activation.
TL;DR: It is demonstrated that the release of soluble tie-1 from endothelial cells is stimulated by inflammatory cytokines and VEGF through the activation of an endothelial membrane-associated metalloprotease.