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Emma Timms
Researcher at Ontario Institute for Cancer Research
Publications - 23
Citations - 16411
Emma Timms is an academic researcher from Ontario Institute for Cancer Research. The author has contributed to research in topics: CD8 & T-cell receptor. The author has an hindex of 21, co-authored 23 publications receiving 15850 citations. Previous affiliations of Emma Timms include Amgen & University of Toronto.
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Journal ArticleDOI
Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation
David L. Lacey,Emma Timms,Hong-Lin Tan,Michael J. Kelley,Colin R. Dunstan,Tim Burgess,Robin Elliott,Anne Colombero,Gary Elliott,S. Scully,Hailing Hsu,John K. Sullivan,Nessa Hawkins,E. Davy,C. Capparelli,Alana Eli,Yi-xin Qian,Steve Kaufman,Ildiko Sarosi,Victoria Shalhoub,Giorgio Senaldi,Jane Guo,John M. Delaney,William J. Boyle +23 more
TL;DR: The effects of OPGL are blocked in vitro and in vivo by OPG, suggesting that OPGl and OPG are key extracellular regulators of osteoclast development.
Journal ArticleDOI
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
Young-Yun Kong,Hiroki Yoshida,Ildiko Sarosi,Hong-Lin Tan,Emma Timms,Casey Capparelli,Sean Morony,Antonio J. Oliveira-dos-Santos,Gwyneth Van,Annick Itie,Wilson Khoo,Andrew Wakeham,Colin R. Dunstan,David L. Lacey,Tak W. Mak,William J. Boyle,Josef M. Penninger +16 more
TL;DR: OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo.
Journal ArticleDOI
Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4
Paul Waterhouse,Josef M. Penninger,Emma Timms,Andrew Wakeham,Arda Shahinian,Kelvin P. Lee,Craig B. Thompson,Henrik Griesser,Tak W. Mak +8 more
TL;DR: Although CTLA-4-deficient T cells proliferated spontaneously and strongly when stimulated through the T cell receptor, they were sensitive to cell death induced by cross-linking of the Fas receptor and by gamma irradiation, and is vital for the control of lymphocyte homeostasis.
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Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
Hailing Hsu,David L. Lacey,Colin R. Dunstan,Irina Solovyev,Anne Colombero,Emma Timms,Hong-Lin Tan,Gary Elliott,Michael J. Kelley,Ildiko Sarosi,Ling Wang,Xing-Zhong Xia,Robin Elliott,Laura Chiu,Tabitha Black,Sheila Scully,Casey Capparelli,Sean Morony,Grant Shimamoto,Michael Bass,William J. Boyle +20 more
TL;DR: Data indicate that OPGL-induced osteoclastogenesis is directly mediated through RANK on osteocLast precursor cells, and polyclonal Ab against the RANK extracellular domain promotes osteoclineogenesis in bone marrow cultures suggesting that RANK activation mediates the effects of OPGl on the osteoc last pathway.
Journal ArticleDOI
Profound block in thymocyte development in mice lacking p56lck.
Thierry Molina,Kenji Kishihara,D. P. Siderovskid,W. van Ewijk,Arumugavadivel Narendran,Emma Timms,Andrew Wakeham,Christopher J. Paige,K.-U. Hartmann,A. Veillette,D. Davidson,T. W. Mak +11 more
TL;DR: The results illustrate the crucial role of this T-cell-specific tyrosine kinase in the thymocyte development, as Lck-deficient mice show a pronounced thymic atrophy, with a dramatic reduction in the double-positive (CD4+CD8+) thymocytes population.