Tadashi Baba

TL;DR: A lysostaphin molecule lacking the C‐terminal targeting signal was enzymatically active but had lost its ability to distinguish between S.aureus and S.simulans cells, indicating that this domain functions to confer target cell specificity to the bacteriolytic molecule.

TL;DR: The genetic basis for the remarkable ability of S. aureus to acquire multi-antibiotic resistance is described, and a novel paradigm for future chemotherapy against the multi-resistant pathogens is proposed.

TL;DR: The data indicated that MRSA clones distinct from H-MRSA have disseminated in healthy children, and the fact that MRC-NS strains were prevalent in the community suggested that they might serve as a reservoir for the SCCmec element carried by MRSA strains disseminatedIn the community.

TL;DR: The results suggest that ligands for the TLR2-TLR6 heterodimer in S. aureus membranes, including diacylated lipoproteins, could promote T(H)2-type inflammation through TSLP production in keratinocytes, providing an overall picture of the vicious cycles between colonization by S.Aureus and AD in the T( H) 2-skewed sensitization process, exacerbation of the disease, or both.

TL;DR: A whole picture of MRSA is provided based on its genetic makeup as a versatile pathogen and its tenacious colonizer to provide a whole picture against MRSA prevailing among immuno-compromised patients in the hospital.