O
Olaf Schneewind
Researcher at University of Chicago
Publications - 360
Citations - 37069
Olaf Schneewind is an academic researcher from University of Chicago. The author has contributed to research in topics: Staphylococcus aureus & Peptidoglycan. The author has an hindex of 98, co-authored 355 publications receiving 34450 citations. Previous affiliations of Olaf Schneewind include Oregon State University & Argonne National Laboratory.
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Journal ArticleDOI
Surface Proteins of Gram-Positive Bacteria and Mechanisms of Their Targeting to the Cell Wall Envelope
TL;DR: The mechanisms for both sorting and targeting of proteins to the envelope of gram-positive bacteria are described and the functions of known surface proteins are reviewed.
Journal ArticleDOI
Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
Jochen Mattner,Kristin L. DeBord,Nahed Ismail,Randal D. Goff,Carlos Cantu,Dapeng Zhou,Pierre Saint-Mezard,Vivien Wang,Ying Gao,Ning Yin,Kasper Hoebe,Olaf Schneewind,David H. Walker,Bruce Beutler,Luc Teyton,Paul B. Savage,Albert Bendelac +16 more
TL;DR: Evidence is reported for microbial, antigen-specific activation of NKT cells against Gram-negative, lipopolysaccharide (LPS)-negative alpha-Proteobacteria such as Ehrlichia muris and Sphingomonas capsulata and shows that glycosylceramides are an alternative to LPS for innate recognition of the Gram- negative, LPS-negative bacterial cell wall.
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Staphylococcus aureus Sortase, an Enzyme that Anchors Surface Proteins to the Cell Wall
TL;DR: The protein specified by srtA, sortase, may be a useful target for the development of new antimicrobial drugs.
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Sortases and the Art of Anchoring Proteins to the Envelopes of Gram-Positive Bacteria
TL;DR: This review focuses on the mechanisms of surface protein anchoring to the cell wall envelope by sortases and the role that these enzymes play in bacterial physiology and pathogenesis.
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Purification and characterization of sortase, the transpeptidase that cleaves surface proteins of Staphylococcus aureus at the LPXTG motif
TL;DR: surface proteins of Staphylococcus aureus are linked to the bacterial cell wall by sortase, an enzyme that cleaves polypeptides at the threonine of the LPXTG motif, a reaction that can be inhibited with sulfhydryl-modifying reagents.