T
Taha Rezai
Researcher at University of California, Santa Cruz
Publications - 3
Citations - 1024
Taha Rezai is an academic researcher from University of California, Santa Cruz. The author has contributed to research in topics: Membrane permeability & Synthetic membrane. The author has an hindex of 3, co-authored 3 publications receiving 876 citations. Previous affiliations of Taha Rezai include Thermo Fisher Scientific.
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Journal ArticleDOI
Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers.
TL;DR: Results of solution NMR studies and hydrogen/deuterium (H/D) exchange experiments showed that membrane diffusion rates correlated with the degree of intramolecular hydrogen bonding and H/D exchange rates.
Journal ArticleDOI
Conformational flexibility, internal hydrogen bonding, and passive membrane permeability: successful in silico prediction of the relative permeabilities of cyclic peptides.
Taha Rezai,Jonathan E. Bock,Mai V. Zhou,Chakrapani Kalyanaraman,R. Scott Lokey,Matthew P. Jacobson +5 more
TL;DR: The results support the hypothesis that the ability to form internal hydrogen bonds is critical for passive membrane permeability and can be the distinguishing factor among closely related compounds, such as those studied here.
Journal ArticleDOI
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds
Tina R White,Chad M. Renzelman,Arthur C Rand,Taha Rezai,Taha Rezai,Cayla M. McEwen,Vladimir Gelev,Rushia A. Turner,Roger G. Linington,Siegfried S. F. Leung,Amit S. Kalgutkar,Jonathan N. Bauman,Yizhong Zhang,Spiros Liras,David Price,Alan M. Mathiowetz,Matthew P. Jacobson,R. Scott Lokey +17 more
TL;DR: A method is reported for the selective, on-resin N-methylation of cyclic peptides to generate compounds with drug-like membrane permeability and oral bioavailability, suggesting that conformation dictates the regiochemistry of the N- methylation reaction.