G
Glenn L. Millhauser
Researcher at University of California, Santa Cruz
Publications - 168
Citations - 9555
Glenn L. Millhauser is an academic researcher from University of California, Santa Cruz. The author has contributed to research in topics: Receptor & Electron paramagnetic resonance. The author has an hindex of 52, co-authored 161 publications receiving 8665 citations. Previous affiliations of Glenn L. Millhauser include University of California, Berkeley & Cornell University.
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Journal ArticleDOI
Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers.
TL;DR: Results of solution NMR studies and hydrogen/deuterium (H/D) exchange experiments showed that membrane diffusion rates correlated with the degree of intramolecular hydrogen bonding and H/D exchange rates.
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A novel α-synuclein missense mutation in Parkinson disease
Christos Proukakis,Christopher G. Dudzik,T Brier,Donna S. Mackay,JM Cooper,Glenn L. Millhauser,Henry Houlden,Anthony H.V. Schapira +7 more
TL;DR: A novel mutation (p.H50Q) is reported in a pathologically proven case of Parkinson disease and is described as a novel missense mutations inα-Synuclein.
Journal ArticleDOI
Molecular Features of the Copper Binding Sites in the Octarepeat Domain of the Prion Protein
Colin S. Burns,Eliah Aronoff-Spencer,Christine M. Dunham,Paula I. Lario,Nikolai I. Avdievich,William E. Antholine,Marilyn M. Olmstead,Alice Vrielink,Gary J. Gerfen,Jack Peisach,William G. Scott,Glenn L. Millhauser +11 more
TL;DR: The structure reveals an unusual complementary interaction between copper-structured HGGGW units that may facilitate molecular recognition between prion proteins, thereby suggesting a mechanism for transmembrane signaling and perhaps conversion to the pathogenic form.
Journal ArticleDOI
Copper binding in the prion protein.
TL;DR: The structural features of the Cu(2+) binding sites have now been characterized and are providing important clues about the normal function of the prion protein and perhaps how metals or loss of protein function play a role in disease.
Journal ArticleDOI
A β-Defensin Mutation Causes Black Coat Color in Domestic Dogs
Sophie I. Candille,Christopher B. Kaelin,Bruce M. Cattanach,Bin Yu,Darren A. Thompson,Matthew A. Nix,Julie A. Kerns,Sheila M. Schmutz,Glenn L. Millhauser,Gregory S. Barsh +9 more
TL;DR: The functional role of β-defensins is expanded, a protein family previously implicated in innate immunity, and an additional class of ligands for signaling through melanocortin receptors is identified, and its protein product binds with high affinity to the Mc1r.