T
Tahmineh Akbarzadeh
Researcher at Tehran University of Medical Sciences
Publications - 133
Citations - 2337
Tahmineh Akbarzadeh is an academic researcher from Tehran University of Medical Sciences. The author has contributed to research in topics: Butyrylcholinesterase & Acetylcholinesterase. The author has an hindex of 23, co-authored 119 publications receiving 1631 citations. Previous affiliations of Tahmineh Akbarzadeh include Payame Noor University & University of Tehran.
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Design and synthesis of novel quinazolinone-1,2,3-triazole hybrids as new anti-diabetic agents: In vitro α-glucosidase inhibition, kinetic, and docking study.
Mina Saeedi,Maryam Mohammadi-Khanaposhtani,Parvaneh Pourrabia,Nima Razzaghi,Reza Ghadimi,Somaye Imanparast,Mohammad Ali Faramarzi,Fatemeh Bandarian,Ensieh Nasli Esfahani,Maliheh Safavi,Hossein Rastegar,Bagher Larijani,Mohammad Mahdavi,Tahmineh Akbarzadeh +13 more
TL;DR: A novel series of quinazolinone-1,2,3-triazole hybrids 10a-p were designed, synthesized, and evaluated for their in vitro α-glucosidase inhibitory activity leading to efficient anti-diabetic agents and lack of cytotoxicity of compounds 10g and 10p was confirmed via MTT assay.
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Synthesis and antibacterial activity of 1-[1,2,4-triazol-3-yl] and 1-[1,3,4-thiadiazol-2-yl]-3-methylthio-6,7-dihydrobenzo[c]thiophen-4(5H)ones.
TL;DR: A series of 1-[1,2,4-triazol-3-yl]-3-methylthio-6,7-dihydrobenzo[c]thiophen-4(5H)ones synthesized and tested to demonstrate in vitro antimicrobial activity exhibited a good activity against Staphylococcus aureus, S. epidermidis and Bacillus subtilis.
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Potent acetylcholinesterase inhibitors: design, synthesis, biological evaluation, and docking study of acridone linked to 1,2,3-triazole derivatives.
Maryam Mohammadi-Khanaposhtani,Mina Saeedi,Narges Shamsaei Zafarghandi,Mohammad Mahdavi,Reyhaneh Sabourian,Elahe Karimpour Razkenari,Heshmatollah Alinezhad,Mahnaz Khanavi,Alireza Foroumadi,Abbas Shafiee,Tahmineh Akbarzadeh +10 more
TL;DR: Docking study confirmed the results obtained through in vitro experiments and predicted possible binding conformation of acridone derivatives and depicted the most potent anti-AChE activity.
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Novel tacrine-coumarin hybrids linked to 1,2,3-triazole as anti-Alzheimer’s compounds: In vitro and in vivo biological evaluation and docking study
Zahra Najafi,Mohammad Mahdavi,Mina Saeedi,Elahe Karimpour-Razkenari,Najmeh Edraki,Mohammad Sharifzadeh,Mahnaz Khanavi,Tahmineh Akbarzadeh +7 more
TL;DR: In vivo studies by Morris water maze task showed that compound 8e significantly reversed scopolamine-induced memory deficit in rats, and compound 8m displayed the best anti-BChE activity much more active than tacrine and donepezil as the reference drugs.
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Novel tacrine-1,2,3-triazole hybrids: In vitro, in vivo biological evaluation and docking study of cholinesterase inhibitors.
Zahra Najafi,Mohammad Mahdavi,Mina Saeedi,Elahe Karimpour-Razkenari,Raymond Asatouri,Fahimeh Vafadarnejad,Farshad Homayouni Moghadam,Mahnaz Khanavi,Mohammad Sharifzadeh,Tahmineh Akbarzadeh +9 more
TL;DR: In vivo studies of compound 5l in Morris water maze task confirmed memory improvement in scopolamine-induced impairment, and molecular modeling and kinetic studies showed that compounds 5l and 5j bound simultaneously to the peripheral anionic site (PAS) and catalytic sites (CS) of the AChE and BChE.