T
Taisia Blokhina
Researcher at Semenov Institute of Chemical Physics
Publications - 11
Citations - 86
Taisia Blokhina is an academic researcher from Semenov Institute of Chemical Physics. The author has contributed to research in topics: Radioresistance & Irradiation. The author has an hindex of 3, co-authored 9 publications receiving 32 citations. Previous affiliations of Taisia Blokhina include Moscow Institute of Physics and Technology.
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Journal ArticleDOI
Residual γH2AX foci induced by low dose x-ray radiation in bone marrow mesenchymal stem cells do not cause accelerated senescence in the progeny of irradiated cells.
Margarita Pustovalova,Тatiana A. Astrelina,Anna Grekhova,Anna Grekhova,Natalia Vorobyeva,Anastasia Tsvetkova,Taisia Blokhina,Victoria Nikitina,Yulia Suchkova,D. Usupzhanova,V. Brunchukov,I. Kobzeva,Тatiana Karaseva,Ivan V. Ozerov,Aleksandr Samoylov,Andrey Bushmanov,Sergey V. Leonov,Sergey V. Leonov,Evgeny Izumchenko,Alex Zhavoronkov,Dmitry Klokov,Dmitry Klokov,Andreyan N. Osipov +22 more
TL;DR: The hypothesis that the low-dose IR induced residual γH2AХ foci do not play a role in delayed irradiation consequences, associated with cellular senescence in cultured MSCs is supported.
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The p53-53BP1-Related Survival of A549 and H1299 Human Lung Cancer Cells after Multifractionated Radiotherapy Demonstrated Different Response to Additional Acute X-ray Exposure.
Margarita Pustovalova,Lina Alhaddad,Nadezhda Smetanina,Anna Chigasova,Anna Chigasova,Taisia Blokhina,Taisia Blokhina,Roman N. Chuprov-Netochin,Andreyan N. Osipov,Andreyan N. Osipov,Sergey V. Leonov,Sergey V. Leonov +11 more
TL;DR: This study provides strong evidence that different DNA repair mechanisms are activated by multifraction radiotherapy (MFR), as well as single-dose IR, and that the enhanced cellular survival after MFR is reliant on both p53 and 53BP1 signaling along with non-homologous end-joining (NHEJ).
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The CD44high Subpopulation of Multifraction Irradiation-Surviving NSCLC Cells Exhibits Partial EMT-Program Activation and DNA Damage Response Depending on Their p53 Status
Margarita Pustovalova,Lina Alhaddad,Taisia Blokhina,Taisia Blokhina,Nadezhda Smetanina,Anna Chigasova,Anna Chigasova,Roman N. Chuprov-Netochin,Petr Eremin,Ilmira Gilmutdinova,Andreyan N. Osipov,Andreyan N. Osipov,Sergey B. Leonov,Sergey B. Leonov +13 more
TL;DR: In this paper, the authors investigated the impact of p53 status on the decay of γH2AX foci and the associated efficacy of DNA double-strand break (DSB) repair in NSCLC cells.
Journal ArticleDOI
IR-Surviving NSCLC Cells Exhibit Different Patterns of Molecular and Cellular Reactions Relating to the Multifraction Irradiation Regimen and p53-Family Proteins Expression.
Lina Alhaddad,Margarita Pustovalova,Taisia Blokhina,Taisia Blokhina,Roman N. Chuprov-Netochin,Andreyan N. Osipov,Andreyan N. Osipov,Sergey B. Leonov,Sergey B. Leonov +8 more
TL;DR: In this paper, the impact of fraction dose escalation (FDE) in the split course and the conventional hypofractionation (HF) on the phenotypic and molecular signatures of four MFR-surviving NSCLC cell sublines were examined.
Journal ArticleDOI
CD44+ and CD133+ Non-Small Cell Lung Cancer Cells Exhibit DNA Damage Response Pathways and Dormant Polyploid Giant Cancer Cell Enrichment Relating to Their p53 Status
Margarita Pustovalova,Taisia Blokhina,Lina Alhaddad,Anna Chigasova,Roman N. Chuprov-Netochin,Alexander Veviorskiy,G. I. Filkov,A. N. Osipov,Sergey B. Leonov +8 more
TL;DR: SA-beta-galhistology revealed that cellular-stress-induced premature senescence (SIPS) likely has a significant influence on the temporary dormant state of H1299 cells and proposed that entering the “quiescence” state rather than p21-mediated SIPS may play a significant role in the survival of p53wt CSC-like NSCLC cells after IR stress.