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Natalia Vorobyeva
Researcher at Semenov Institute of Chemical Physics
Publications - 17
Citations - 200
Natalia Vorobyeva is an academic researcher from Semenov Institute of Chemical Physics. The author has contributed to research in topics: Irradiation & DNA damage. The author has an hindex of 7, co-authored 10 publications receiving 136 citations. Previous affiliations of Natalia Vorobyeva include Johns Hopkins University.
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Journal ArticleDOI
Formation of γH2AX and pATM Foci in Human Mesenchymal Stem Cells Exposed to Low Dose-Rate Gamma-Radiation
Stepan Ulyanenko,Margarita Pustovalova,Sergey Koryakin,Evgenii Beketov,Anatolii Lychagin,Liliya Ulyanenko,Andrey Kaprin,Anna Grekhova,Alexandra M. Ozerova,Ivan V. Ozerov,Natalia Vorobyeva,Peter Shegay,S.A. Ivanov,Sergey V. Leonov,Dmitry Klokov,Andreyan N. Osipov +15 more
TL;DR: Non-linear dose responses for γH2AX and pATM foci in human MSCs exposed to low dose-rate IR are demonstrated and the existence of a threshold is shown, which may have implications for radiation protection in humans.
Journal ArticleDOI
γH2AX, 53BP1 and Rad51 protein foci changes in mesenchymal stem cells during prolonged X-ray irradiation
Anastasia Tsvetkova,Ivan V. Ozerov,Margarita Pustovalova,Anna Grekhova,Anna Grekhova,Petr Eremin,Natalia Vorobyeva,I.I. Eremin,A. L. Pulin,V.L. Zorin,Pavel Kopnin,Sergey V. Leonov,Alex Zhavoronkov,Dmitry Klokov,Andreyan N. Osipov +14 more
TL;DR: The data suggest that prolonged exposure of MSCs to ionizing radiation leads to cell cycle redistribution and associated activation of homologous recombination, and proliferation status may significantly affect the biological outcome.
Journal ArticleDOI
Activation of homologous recombination DNA repair in human skin fibroblasts continuously exposed to X-ray radiation
Andreyan N. Osipov,Anna Grekhova,Margarita Pustovalova,Ivan V. Ozerov,Petr Eremin,Natalia Vorobyeva,Natalia Lazareva,A. L. Pulin,Alex Zhavoronkov,Sergey A. Roumiantsev,Dmitry Klokov,I.I. Eremin +11 more
TL;DR: The observed activation of the error-free homologous recombination DNA double-strand break repair pathway suggests compensatory adaptive mechanisms that may help alleviate long-term biological consequences and could potentially be utilized both in radiation protection and medical practices.
Journal ArticleDOI
Residual γH2AX foci induced by low dose x-ray radiation in bone marrow mesenchymal stem cells do not cause accelerated senescence in the progeny of irradiated cells.
Margarita Pustovalova,Тatiana A. Astrelina,Anna Grekhova,Anna Grekhova,Natalia Vorobyeva,Anastasia Tsvetkova,Taisia Blokhina,Victoria Nikitina,Yulia Suchkova,D. Usupzhanova,V. Brunchukov,I. Kobzeva,Тatiana Karaseva,Ivan V. Ozerov,Aleksandr Samoylov,Andrey Bushmanov,Sergey V. Leonov,Sergey V. Leonov,Evgeny Izumchenko,Alex Zhavoronkov,Dmitry Klokov,Dmitry Klokov,Andreyan N. Osipov +22 more
TL;DR: The hypothesis that the low-dose IR induced residual γH2AХ foci do not play a role in delayed irradiation consequences, associated with cellular senescence in cultured MSCs is supported.
Journal ArticleDOI
Acquired resistance to tyrosine kinase inhibitors may be linked with the decreased sensitivity to X-ray irradiation.
Maxim Sorokin,R. V. Kholodenko,Anna Grekhova,Maria Suntsova,Margarita Pustovalova,Natalia Vorobyeva,I. V. Kholodenko,Galina Malakhova,Andrew Garazha,Artem V. Nedoluzhko,R. G. Vasilov,Elena Poddubskaya,Olga Kovalchuk,Leila Adamyan,V.S. Prassolov,Daria Allina,Denis Kuzmin,Kirill Ignatev,Andreyan N. Osipov,Anton Buzdin +19 more
TL;DR: The results provide a new cell culture model for studying anti-cancer therapy efficiency and evidence that there may be a tissue-specific radioresistance emerging as a side effect of treatment with TKIs.