T
Takao Ohtsuka
Researcher at Kyushu University
Publications - 285
Citations - 7415
Takao Ohtsuka is an academic researcher from Kyushu University. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 39, co-authored 245 publications receiving 5896 citations. Previous affiliations of Takao Ohtsuka include Saga University & University of Iowa Hospitals and Clinics.
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Journal ArticleDOI
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Masao Tanaka,Carlos Fernandez-del Castillo,Terumi Kamisawa,Jin-Young Jang,Philippe Lévy,Takao Ohtsuka,Roberto Salvia,Yasuhiro Shimizu,Minoru Tada,Christopher L. Wolfgang +9 more
TL;DR: The working group has revised the guidelines regarding prediction of invasive carcinoma and high-grade dysplasia, surveillance, and postoperative follow-up of IPMN and includes updated information and recommendations based on the current understanding.
Journal ArticleDOI
ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway.
Takao Ohtsuka,Hoon Ryu,Yohji A. Minamishima,Salvador Macip,Junji Sagara,Keiichi I. Nakayama,Stuart A. Aaronson,Sam W. Lee +7 more
TL;DR: Evidence is presented that ASC can function as an adaptor molecule for Bax and regulate a p53–Bax mitochondrial pathway of apoptosis and induction of ASC after exposure to genotoxic stress is dependent on p53.
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Intraductal Papillary-Mucinous Tumor of the Pancreas Concomitant with Ductal Carcinoma of the Pancreas
TL;DR: Clinicians should pay attention to the possible presence of DC of the pancreas in male patients with intraductal papillary-mucinous adenoma of the Pancreas of branch type in their 6th to 8th decades.
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Autophagy is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice.
Sho Endo,Kohei Nakata,Kenoki Ohuchida,Shin Takesue,Hiromichi Nakayama,Toshiya Abe,Kazuhiro Koikawa,Takashi Okumura,Masafumi Sada,Kohei Horioka,Biao Zheng,Yusuke Mizuuchi,Chika Iwamoto,Masaharu Murata,Taiki Moriyama,Yoshihiro Miyasaka,Takao Ohtsuka,Kazuhiro Mizumoto,Yoshinao Oda,Makoto Hashizume,Masafumi Nakamura +20 more
TL;DR: Autophagic PSCs produce ECM molecules and interleukin 6 and are associated with shorter survival times and disease recurrence in patients with pancreatic cancer, and inhibitors of PSC autophagy might reduce pancreatic tumor invasiveness by altering the tumor stroma.
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Gene Expression Levels as Predictive Markers of Outcome in Pancreatic Cancer after Gemcitabine-Based Adjuvant Chemotherapy
Hayato Fujita,Kenoki Ohuchida,Kazuhiro Mizumoto,Soichi Itaba,Tetsuhide Ito,Kohei Nakata,Jun Yu,Tadashi Kayashima,Ryota Souzaki,Tatsuro Tajiri,Tatsuya Manabe,Takao Ohtsuka,Masao Tanaka +12 more
TL;DR: Quantitative analyses of hENT1, dCK, RRM1, and RRM2 mRNA levels using FFPE tissue samples and microdissected neoplastic cells from EUS-FNA cytologic specimens may be useful in predicting the gemcitabine sensitivity of patients with PDAC.