T
Takao Sakamoto
Researcher at Tohoku University
Publications - 65
Citations - 2259
Takao Sakamoto is an academic researcher from Tohoku University. The author has contributed to research in topics: Catalysis & Indole test. The author has an hindex of 25, co-authored 65 publications receiving 2173 citations. Previous affiliations of Takao Sakamoto include University of Tokyo.
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Journal ArticleDOI
TMP−Zincate as Highly Chemoselective Base for Directed Ortho Metalation
Journal ArticleDOI
Development of an Efficient Procedure for Indole Ring Synthesis from 2-Ethynylaniline Derivatives Catalyzed by Cu(II) Salts and Its Application to Natural Product Synthesis
TL;DR: The formal and total synthesis of hippadine with the Cu(II)-promoted indole synthesis as the key step was accomplished and the sequential cyclization was realized to provide the tricyclic ring systems but it was limited to five- and six-membered rings for the second cyclization.
Journal ArticleDOI
Generation of Functionalized Asymmetric Benzynes with TMP-Zincates. Effects of Ligands on Selectivity and Reactivity of Zincates
Masanobu Uchiyama,Tomoko Miyoshi,Yumiko Kajihara,Takao Sakamoto,Yuko Otani,Tomohiko Ohwada,Yoshinori Kondo +6 more
TL;DR: New methods for preparing functionalized benzynes through deprotonative zincation as a key reaction using R2Zn(TMP)Li are developed and the utility of spectator ligands on the central metal of ate complexes as a tunable functionality in the development of new ate complex-promoted reactions is highlighted.
Journal ArticleDOI
Novel synthetic strategy of carbolines via palladium-catalyzed amination and arylation reaction
TL;DR: In this article, four parent carbolines and their corresponding 5- or 9-methylsulfonyl derivatives were synthesized by the palladium-catalyzed intramolecular arylation reaction of ortho-bromo-substituted anilinopyridines.
Journal ArticleDOI
Generation and suppression of 3-/4-functionalized benzynes using zinc ate base (TMP-Zn-ate): new approaches to multisubstituted benzenes.
Masanobu Uchiyama,Yuri Kobayashi,Taniyuki Furuyama,Shinji Nakamura,Yumiko Kajihara,Tomoko Miyoshi,Takao Sakamoto,Yoshinori Kondo,Keiji Morokuma +8 more
TL;DR: These methods offer far greater generality than previous methods for the synthesis of multifunctionalized benzenes with lithium di-alkyl(2,2,6,6-tetramethylpiperidino)zincate (R2Zn(TMP)Li) through deprotonative zincation as a key reaction.