T
Takashi Isobe
Researcher at Kobe University
Publications - 78
Citations - 1146
Takashi Isobe is an academic researcher from Kobe University. The author has contributed to research in topics: Amyloidosis & Bence Jones protein. The author has an hindex of 17, co-authored 78 publications receiving 1128 citations. Previous affiliations of Takashi Isobe include Tokyo Metropolitan University.
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Journal ArticleDOI
Patterns of amyloidosis and their association with plasma-cell dyscrasia, monoclonal immunoglobulins and Bence-Jones proteins.
TL;DR: It is postulated that amyloid-related monoclonal immunoglobulins and Bence-Jones proteins may be autoantibodies or fragments of autoantIBodies directed against normal tissue constituents.
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Diagnosis of familial amyloidotic polyneuropathy by recombinant DNA techniques.
Hiroyuki Sasaki,Yoshiyuki Sakaki,H. Matsuo,Ikuo Goto,Y. Kuroiwa,I. Sahashi,Akira Takahashi,Tomotaka Shinoda,Takashi Isobe,Yasuyuki Takagi +9 more
TL;DR: CDNA for normal human prealbumin was cloned and its nucleotide sequence was determined, and results showed that the nucleotide substitution responsible for the Val----Met change results in formation of new restriction sites for BalI and NsiI.
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Structural Identity of Bence Jones and Amyloid Fibril Proteins in a Patient with Plasma Cell Dyscrasia and Amyloidosis
William D. Terry,David L. Page,Shigeru Kimura,Takashi Isobe,Elliott F. Osserman,George G. Glenner +5 more
TL;DR: It appears that the predominant protein present in the amyloid deposits in this patient was an intact kappa-type light polypeptide chain that was identical with the urinary Bence Jones protein.
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Establishment of a myeloid leukaemic cell line (SKNO‐1) from a patient with t(8;21) who acquired monosomy 17 during disease progression
Sachiko Matozaki,Toshitaro Nakagawa,Ryuji Kawaguchi,Ryoji Aozaki,Masayoshi Tsutsumi,Tohru Murayama,Tamio Koizumi,Ryuichiro Nishimura,Takashi Isobe,Kazuo Chihara +9 more
TL;DR: A novel cell line SKNO‐1 was established from the bone marrow cells of a 22‐year‐old male suffering from acute myeloblastic leukaemia (AML) M2 with t(8;21) whose disease became resistant to chemotherapy after acquisition of 17 monosomy.
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Expression of α and β genes of human chorionic gonadotropin in lung cancer
Tohru Yokotani,Tamio Koizumi,Rika Taniguchi,Toshitaro Nakagawa,Takashi Isobe,Masahiro Yoshimura,Noriaki Tsubota,Kazuo Hasegawa,Nakaaki Ohsawa,Shigeaki Baba,Hirokazu Yasui,Ryuichiro Nishimura +11 more
TL;DR: The results strongly suggests the production of hCGβ as being part of the phenotype of malignantly transformed lung cells and further strengthen its superior specificity over intact hCG or hCGα as a tumor marker for lung cancers.