T
Takashi Kageyama
Researcher at Primate Research Institute
Publications - 126
Citations - 3357
Takashi Kageyama is an academic researcher from Primate Research Institute. The author has contributed to research in topics: Pepsinogen A & Pepsinogen C. The author has an hindex of 31, co-authored 126 publications receiving 3254 citations. Previous affiliations of Takashi Kageyama include Nagoya Bunri University & Kyoto University.
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Journal ArticleDOI
The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier.
Takashi Kageyama,Masaru Nakamura,Akinori Matsuo,Yasuomi Yamasaki,Yoshinobu Takakura,Mitsuru Hashida,Yoshikatsu Kanai,Mikihiko Naito,Takashi Tsuruo,Nagahiro Minato,Shun Shimohama +10 more
TL;DR: This is the first report showing that the 4F2hc/LAT1 complex participates in L-DOPA transport across the BBB, and it is demonstrated that LAT1 is predominantly expressed in the microvessels of the central nervous system.
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Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development.
TL;DR: Phylogenetic analyses based on amino acid and nucleotide sequences indicate that progastricsin diverged first followed by prochymosin, and that pepsinogens A and F are most closely related.
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Characterization of New Fluorogenic Substrates for the Rapid and Sensitive Assay of Cathepsin E and Cathepsin D
Yoshiyuki Yasuda,Takashi Kageyama,Akifumi Akamine,Masahiro Shibata,Eiki Kominami,Yasuo Uchiyama,Kenji Yamamoto +6 more
TL;DR: This study designed and constructed highly sensitive synthetic decapeptide substrates for assays of cathepsins E and D based on the known sequence specificities of their cleavage sites, suggesting that amino acids at positions far from the cleavage site are important for discrimination between the two enzymes.
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Radioimmunoassay of serum group I and group II pepsinogens in normal controls and patients with various disorders
M. Ichinose,Kazumasa Miki,Chie Furihata,Takashi Kageyama,R. Hayashi,Hirohumi Niwa,Hiroshi Oka,Taijiro Matsushima,K. Takahashi +8 more
TL;DR: A radioimmunoassay for human group I pepsinogens (PgI) in serum was developed, using PgI purified from gastric mucosa, which was satisfactory for clinical use.
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Tuna pepsinogens and pepsins
TL;DR: Three pepsinogens (pepsinogens 1, 2, and 3) were purified from the gastric mucosa of the North Pacific bluefin tuna and a phylogenetic tree for 16 aspartic proteinase zymogens including the three tuna pepinogens was constructed based on the amino acid sequences of their activation segments.