T
Takashi Sekine
Researcher at Toho University
Publications - 100
Citations - 5389
Takashi Sekine is an academic researcher from Toho University. The author has contributed to research in topics: Organic anion transporter 1 & Proximal renal tubular acidosis. The author has an hindex of 34, co-authored 100 publications receiving 5185 citations. Previous affiliations of Takashi Sekine include University of Tokyo & Kyorin University.
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Expression Cloning and Characterization of a Novel Multispecific Organic Anion Transporter
TL;DR: The isolation of a novel complementary DNA from rat kidney that encodes a 551-amino acid residue protein (OAT1) with 12 putative membrane-spanning domains suggests that OAT1 is a multispecific organic anion transporter at the basolateral membrane of the proximal tubule.
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Molecular Cloning and Characterization of a New Multispecific Organic Anion Transporter from Rat Brain
Hiroyuki Kusuhara,Takashi Sekine,Naoko Utsunomiya-Tate,Minoru Tsuda,Ryoji Kojima,Seok Ho Cha,Yuichi Sugiyama,Yoshikatsu Kanai,Hitoshi Endou +8 more
TL;DR: A cDNA encoding the new member of the multispecific organic anion transporter family, OAT3, was isolated by the reverse transcription-polymerase chain reaction cloning method and northern blot analysis revealed that rat Oat3 mRNA is expressed in the liver, brain, kidney, and eye.
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Identification of multispecific organic anion transporter 2 expressed predominantly in the liver
Takashi Sekine,Seok Ho Cha,Minoru Tsuda,Nopporn Apiwattanakul,Noriko Nakajima,Yoshikatsu Kanai,Hitoshi Endou +6 more
TL;DR: It is demonstrated that NLT (novel liver‐specific transport protein) is a multispecific organic anion transporter of the liver, and the amino acid sequence of NLT shows 42% identity to that of the renal multisPEcific organicAnion transporter, OAT1.
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Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney.
TL;DR: Results indicate that hOAT1 is a multispecific organic anion transporter on the basolateral membrane of the proximal tubule in human kidney.
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Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities.
Takashi Igarashi,Jun Inatomi,Takashi Sekine,Seok Ho Cha,Yoshikatsu Kanai,Motoei Kunimi,Kazuhisa Tsukamoto,Hiroaki Satoh,Mitsunobu Shimadzu,Fumiko Tozawa,Tetsuo Mori,Masaaki Shiobara,George Seki,Hitoshi Endou +13 more
TL;DR: Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities and can lead to blindness in women and severe brain damage in men.