T
Takato Takenouchi
Researcher at National Agriculture and Food Research Organization
Publications - 121
Citations - 3265
Takato Takenouchi is an academic researcher from National Agriculture and Food Research Organization. The author has contributed to research in topics: Receptor & Neurodegeneration. The author has an hindex of 32, co-authored 118 publications receiving 2848 citations. Previous affiliations of Takato Takenouchi include University of Tsukuba.
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Journal ArticleDOI
Inhibitory effects of U73122 and U73343 on Ca2+ influx and pore formation induced by the activation of P2X7 nucleotide receptors in mouse microglial cell line
TL;DR: U73122, but not U73343, inhibited the transient [Ca2+]i increase involving Ca2+ release from intracellular stores through PLC activation, suggesting possible PLC-independent blockage of the process of P2X7-associated channel and pore formations by U-compounds in C57BL/6 mouse microglial cells.
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The Activation of P2X7 Receptor Impairs Lysosomal Functions and Stimulates the Release of Autophagolysosomes in Microglial Cells
Takato Takenouchi,Masaaki Nakai,Yoshifumi Iwamaru,Shuei Sugama,Mitsutoshi Tsukimoto,Masayo Fujita,Jianshe Wei,Akio Sekigawa,Mitsuru Sato,Shuji Kojima,Hiroshi Kitani,Makoto Hashimoto +11 more
TL;DR: A novel mechanism whereby the P2X7R signaling pathway may negatively regulate autophagic flux through the impairment of lysosomal functions, leading to stimulation of a release of autophagolysosomes/phagolySosomes into the extracellular space is suggested.
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P2X7 Receptor Signaling Pathway as a Therapeutic Target for Neurodegenerative Diseases
Takato Takenouchi,Kazunari Sekiyama,Akio Sekigawa,Masayo Fujita,Masaaki Waragai,Shuei Sugama,Yoshifumi Iwamaru,Hiroshi Kitani,Makoto Hashimoto +8 more
TL;DR: The expression and function of the P2X7 receptor (P2X 7R), an ATP-gated ion channel abundantly expressed in microglia in the brain, is significantly up-regulated in the postmortem brain of Alzheimer’s disease patients and various neurodegenerative disease animal models, raising the possibility that the P1X7R signaling pathway could be a therapeutic target for treating various neuro degenerative diseases.
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Angiopoietin-1/Tie2 Signal Augments Basal Notch Signal Controlling Vascular Quiescence by Inducing Delta-Like 4 Expression through AKT-mediated Activation of β-Catenin
Jianghui Zhang,Shigetomo Fukuhara,Keisuke Sako,Takato Takenouchi,Hiroshi Kitani,Tsutomu Kume,Gou Young Koh,Naoki Mochizuki +7 more
TL;DR: Angiopoietin-1 regulates both vascular quiescence and angiogenesis through the receptor tyrosine kinase Tie2 and it is demonstrated that the former up-regulates Notch ligand delta-like 4 (Dll4) only in the presence of cell-cell contacts.
Journal ArticleDOI
Structure, tissue distribution, and pharmacological characterization of xenopus orexins
Megumi Shibahara,Takeshi Sakurai,Tadahiro Nambu,Takato Takenouchi,Hisashi Iwaasa,Shin-Ichiro Egashira,Masaki Ihara,Katsutoshi Goto +7 more
TL;DR: Results suggest that Xenopus orexin-B might be a useful pharmacological tool as an OX2R selective high-affinity agonist in submammalian chordates.