M
Masaki Ihara
Researcher at Merck & Co.
Publications - 19
Citations - 1560
Masaki Ihara is an academic researcher from Merck & Co.. The author has contributed to research in topics: Receptor & Neuropeptide Y receptor. The author has an hindex of 12, co-authored 19 publications receiving 1544 citations.
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Journal ArticleDOI
Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788
K. Ishikawa,Masaki Ihara,K. Noguchi,T. Mase,N. Mino,T Saeki,Takahiro Fukuroda,Takehiro Fukami,S. Ozaki,Takahiro Nagase +9 more
TL;DR: Being a potent and selective ETB receptor antagonist, BQ-788 may be considered as a powerful tool for investigating the role of ET in physiological and pathological processes.
Journal ArticleDOI
Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice.
Akio Kanatani,Satoshi Mashiko,Naomi Murai,Sugimoto N,Junko Ito,Takahiro Fukuroda,Takehiro Fukami,Nancy R. Morin,Douglas J. MacNeil,Van der Ploeg Lh,Saga Y,Nishimura S,Masaki Ihara +12 more
TL;DR: It is concluded that multiple NPY receptors, possibly including the novel feeding receptor, are involved in the feeding response evoked by NPY and its analogs, among them the Y1 receptor plays a key role in NPY-induced feeding in mice.
Journal ArticleDOI
Potent neuropeptide Y Y1 receptor antagonist, 1229U91: blockade of neuropeptide Y-induced and physiological food intake
TL;DR: It is shown that a peptide, 1229U91, is a potent and selective antagonist for Y1 receptors, and that physiological feeding behavior after overnight fasting may be largely regulated by NPY via Y 1 receptors.
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A typical Y1 receptor regulates feeding behaviors: effects of a potent and selective Y1 antagonist, J-115814.
Akio Kanatani,Mikiko Hata,Satoshi Mashiko,Akane Ishihara,Osamu Okamoto,Yuji Haga,Tomoyuki Ohe,Tetsuya Kanno,Naomi Murai,Yasuyuki Ishii,Takahiro Fukuroda,Takehiro Fukami,Masaki Ihara +12 more
TL;DR: It is certified that the Y1 receptor is a major feeding receptor of NPY by using the potent and selective Y1 antagonist J-115814 and concluding that theY1 receptor plays a key role in regulating food intake.
Journal ArticleDOI
Structure, tissue distribution, and pharmacological characterization of xenopus orexins
Megumi Shibahara,Takeshi Sakurai,Tadahiro Nambu,Takato Takenouchi,Hisashi Iwaasa,Shin-Ichiro Egashira,Masaki Ihara,Katsutoshi Goto +7 more
TL;DR: Results suggest that Xenopus orexin-B might be a useful pharmacological tool as an OX2R selective high-affinity agonist in submammalian chordates.