T
Takatoshi Arakawa
Researcher at University of Tokyo
Publications - 56
Citations - 1824
Takatoshi Arakawa is an academic researcher from University of Tokyo. The author has contributed to research in topics: Active site & Glycoside hydrolase. The author has an hindex of 18, co-authored 56 publications receiving 1467 citations. Previous affiliations of Takatoshi Arakawa include Kyoto University & Tokyo University of Agriculture and Technology.
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Journal ArticleDOI
G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody
Tomoya Hino,Takatoshi Arakawa,Hiroko Iwanari,Takami Yurugi-Kobayashi,Chiyo Ikeda-Suno,Yoshiko Nakada-Nakura,Osamu Kusano-Arai,Simone Weyand,Tatsuro Shimamura,Norimichi Nomura,Alexander D. Cameron,Takuya Kobayashi,Takao Hamakubo,So Iwata,Takeshi Murata +14 more
TL;DR: The raising of a mouse monoclonal antibody against human A2AAR that prevents agonist but not antagonist binding to the extracellular ligand-binding pocket is reported and results suggest a new strategy to modulate the activity of G-protein-coupled receptors.
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Crystal structure of the anion exchanger domain of human erythrocyte band 3
Takatoshi Arakawa,Takami Kobayashi-Yurugi,Yilmaz Alguel,Hiroko Iwanari,Hinako Hatae,Momi Iwata,Yoshito Abe,Tomoya Hino,Chiyo Ikeda-Suno,Hiroyuki Kuma,Dongchon Kang,Takeshi Murata,Takao Hamakubo,Alexander D. Cameron,Takuya Kobayashi,Naotaka Hamasaki,So Iwata +16 more
TL;DR: The crystal structure of the transmembrane anion exchanger domain of AE1 is reported, which includes 14 trans Membrane helices and provides a basis for understanding the effects of mutations that lead to red blood cell diseases and also gives insight into the mechanism of ion transport.
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Structure and mechanism of the mammalian fructose transporter GLUT5
Norimichi Nomura,Grégory Verdon,Hae Joo Kang,Hae Joo Kang,Tatsuro Shimamura,Yayoi Nomura,Yo Sonoda,Saba Abdul Hussien,Aziz Abdul Qureshi,Mathieu Coincon,Yumi Sato,Hitomi Abe,Yoshiko Nakada-Nakura,Tomoya Hino,Takatoshi Arakawa,Osamu Kusano-Arai,Hiroko Iwanari,Takeshi Murata,Takuya Kobayashi,Takao Hamakubo,Michihiro Kasahara,So Iwata,David A. Drew,David A. Drew +23 more
TL;DR: It is shown that a single point mutation is enough to switch the substrate-binding preference of GLUT5 from fructose to glucose, and local asymmetric rearrangements of carboxy-terminal transmembrane bundle helices TM7 and TM10 underlie a ‘gated-pore’ transport mechanism in such monosaccharide transporters.
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Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepin
Kanako Terakado Kimura,Hidetsugu Asada,Asuka Inoue,Asuka Inoue,Francois Marie Ngako Kadji,Dohyun Im,Chihiro Mori,Takatoshi Arakawa,Kunio Hirata,Yayoi Nomura,Norimichi Nomura,Junken Aoki,So Iwata,Tatsuro Shimamura +13 more
TL;DR: The structures of human 5-HT2AR in complex with the second-generation antipsychotics risperidone and zotepine effectively stabilize the inactive conformation by forming direct contacts with the residues at the bottom of the ligand-binding pocket, the movements of which are important for receptor activation.
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Rho and Anillin-dependent Control of mDia2 Localization and Function in Cytokinesis
Sadanori Watanabe,Katsuya Okawa,Takashi Miki,Satoko Sakamoto,Tomoko Morinaga,Kohei Segawa,Takatoshi Arakawa,Makoto Kinoshita,Toshimasa Ishizaki,Shuh Narumiya +9 more
TL;DR: Diaphanous-related formin, mDia, is an actin nucleation/polymerization factor functioning downstream of the small GTPase Rho that is required for the localization and function of mDIA2 in cytokinesis.