T
Takayoshi Suzuki
Researcher at Osaka University
Publications - 269
Citations - 8113
Takayoshi Suzuki is an academic researcher from Osaka University. The author has contributed to research in topics: Histone deacetylase & Acetylation. The author has an hindex of 47, co-authored 257 publications receiving 7161 citations. Previous affiliations of Takayoshi Suzuki include Japanese Foundation for Cancer Research & Nagoya University.
Papers
More filters
Journal ArticleDOI
Epigenetic Status of Gdnf in the Ventral Striatum Determines Susceptibility and Adaptation to Daily Stressful Events
Shusaku Uchida,Kumiko Hara,Ayumi Kobayashi,Koji Otsuki,Hirotaka Yamagata,Teruyuki Hobara,Takayoshi Suzuki,Naoki Miyata,Yoshifumi Watanabe +8 more
TL;DR: The data provide insights into the molecular mechanisms underlying the susceptibility and adaptation to chronic stress within the brain, suggesting that epigenetic modifications of Gdnf, along with genetic and environmental factors, contribute to behavioral responses to stress.
Journal ArticleDOI
Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (groups 1, 2A and 2B) the summary report of the 6th collaborative study by CSGMT/JEMS MMS. Collaborative Study of the Micronucleus Group Test. Mammalian Mutagenicity Study Group.
Takeshi Morita,Norihide Asano,Takumi Awogi,Yu F. Sasaki,Sei-ichi Sato,Hiroyasu Shimada,Sizuyo Sutou,Takayoshi Suzuki,Akihiro Wakata,Toshio Sofuni,Makoto Hayashi +10 more
TL;DR: In the 6th MMS/CSGMT collaborative study as mentioned in this paper, IARC groups 1 (human carcinogen), 2A (probable human carcinogen) and 2B (possible human carcinogens) were selected from 100 commercially available chemicals and chemical groups on which there was little or no micronucleus assay data.
Journal ArticleDOI
Identification of cell-active lysine specific demethylase 1-selective inhibitors.
Rie Ueda,Takayoshi Suzuki,Koshiki Mino,Hiroki Tsumoto,Hidehiko Nakagawa,Makoto Hasegawa,Ryuzo Sasaki,Tamio Mizukami,Naoki Miyata +8 more
TL;DR: The first small-molecule LSD1-selective inhibitors are identified and show in vivo H3K4-methylating activity and antiproliferative activity and should be useful as lead structures for anticancer drugs and as tools for studying the biological roles of LSD1.
Journal ArticleDOI
New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation.
Ayako Kimata,Hidehiko Nakagawa,Ryo Ohyama,Tomoko Fukuuchi,Shigeru Ohta,Katsumi Doh-ura,Takayoshi Suzuki,Naoki Miyata +7 more
TL;DR: Findings from studies on physicochemical and biochemical properties suggest that the action mechanism of these compounds does not correlate with any antioxidant activities, any of hydroxyl radical scavenging activities, or any SOD-like activities.
Journal ArticleDOI
Design, Synthesis, Enzyme-Inhibitory Activity, and Effect on Human Cancer Cells of a Novel Series of Jumonji Domain-Containing Protein 2 Histone Demethylase Inhibitors
Shohei Hamada,Takayoshi Suzuki,Takayoshi Suzuki,Koshiki Mino,Koichi Koseki,Felix Oehme,Ingo Flamme,Hiroki Ozasa,Yukihiro Itoh,Daisuke Ogasawara,Haruka Komaarashi,Aiko Kato,Hiroki Tsumoto,Hidehiko Nakagawa,Makoto Hasegawa,Ryuzo Sasaki,Tamio Mizukami,Naoki Miyata +17 more
TL;DR: Findings suggest that combination treatment with JMJD2 inhibitors and LSD1 inhibitors may represent a novel strategy for anticancer chemotherapy.