T
Takayuki Hishiki
Researcher at Kyoto University
Publications - 42
Citations - 2882
Takayuki Hishiki is an academic researcher from Kyoto University. The author has contributed to research in topics: Virus & Viral replication. The author has an hindex of 18, co-authored 36 publications receiving 2540 citations. Previous affiliations of Takayuki Hishiki include Institute of Medical Science & Chiba Institute of Technology.
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Journal ArticleDOI
The lipid droplet is an important organelle for hepatitis C virus production.
Yusuke Miyanari,Kimie Atsuzawa,Nobuteru Usuda,Koichi Watashi,Takayuki Hishiki,Margarita Zayas,Ralf Bartenschlager,Takaji Wakita,Makoto Hijikata,Kunitada Shimotohno +9 more
TL;DR: A novel function of LDs is revealed in the assembly of infectious HCV and a new perspective on how viruses usurp cellular functions is provided.
Journal ArticleDOI
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125
Kei-ichiro Arimoto,Hitoshi Takahashi,Takayuki Hishiki,Hideyuki Konishi,Takashi Fujita,Kunitada Shimotohno +5 more
TL;DR: It is found that RIG-I undergoes proteasomal degradation after conjugation to ubiquitin by RNF125, which constitutes a negative regulatory loop circuit for IFN production.
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Diverse Effects of Cyclosporine on Hepatitis C Virus Strain Replication
Naoto Ishii,Koichi Watashi,Takayuki Hishiki,Kaku Goto,Daisuke Inoue,Makoto Hijikata,Takaji Wakita,Nobuyuki Kato,Kunitada Shimotohno +8 more
TL;DR: It is observed that the presence of viral structural proteins does not influence the anti-HCV activity of CsA, and this provides an insight into the mechanisms of diversity governing virus-cell interactions and in the sensitivity of these strains to antiviral agents.
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Evaluation of the anti-hepatitis C virus effects of cyclophilin inhibitors, cyclosporin A, and NIM811
Kaku Goto,Koichi Watashi,Takayuki Murata,Takayuki Hishiki,Makoto Hijikata,Kunitada Shimotohno +5 more
TL;DR: Both CyP inhibitors rapidly reduced HCV RNA levels even further in combination with IFNalpha without modifying theIFNalpha signal transduction pathway, and may provide a novel strategy for anti-HCV treatment.
Journal ArticleDOI
Infectivity of Hepatitis C Virus Is Influenced by Association with Apolipoprotein E Isoforms
Takayuki Hishiki,Yuko Shimizu,Reiri Tobita,Kazuo Sugiyama,Kazuya Ogawa,Kenji Funami,Yuki Ohsaki,Toyoshi Fujimoto,Hiroshi Takaku,Takaji Wakita,Thomas F. Baumert,Yusuke Miyanari,Kunitada Shimotohno +12 more
TL;DR: It is found that the infectivity of HCV required both the LDLR and scavenger receptor class B, member I (SR-BI), ligands for ApoE, indicating that ApiE is an essential apolipoprotein for HCV infectivity.