T
Tsuneo Kobayashi
Researcher at Hoshi University
Publications - 168
Citations - 4842
Tsuneo Kobayashi is an academic researcher from Hoshi University. The author has contributed to research in topics: Endothelium & Mesenteric arteries. The author has an hindex of 37, co-authored 158 publications receiving 4498 citations.
Papers
More filters
Journal ArticleDOI
Impaired Insulin Signaling in Endothelial Cells Reduces Insulin-Induced Glucose Uptake by Skeletal Muscle
Tetsuya Kubota,Naoto Kubota,Hiroki Kumagai,Shinichi Yamaguchi,Hideki Kozono,Takehiro Takahashi,Mariko Inoue,Shinsuke Itoh,Iseki Takamoto,Takayoshi Sasako,Katsuyoshi Kumagai,Tomoko Kawai,Shinji Hashimoto,Tsuneo Kobayashi,Maki Sato,Kumpei Tokuyama,Satoshi Nishimura,Masaki Tsunoda,Tomohiro Ide,Koji Murakami,Tomomi Yamazaki,Osamu Ezaki,Koichi Kawamura,Hirotake Masuda,Masao Moroi,Kaoru Sugi,Yuichi Oike,Hiroaki Shimokawa,Nobuyuki Yanagihara,Masato Tsutsui,Yasuo Terauchi,Kazuyuki Tobe,Ryozo Nagai,Katsuo Kamata,Kenji Inoue,Tatsuhiko Kodama,Kohjiro Ueki,Takashi Kadowaki +37 more
TL;DR: The results show that insulin signaling in endothelial cells plays a pivotal role in the regulation of glucose uptake by skeletal muscle, and improving endothelial insulin signaling may serve as a therapeutic strategy for ameliorating skeletal muscle insulin resistance.
Journal ArticleDOI
Role of Lysophosphatidylcholine (LPC) in Atherosclerosis
TL;DR: The entirety of the signal-transduction system for LPC, its pathophysiological implications, and the vascular abnormalities associated with it are focused on.
Journal ArticleDOI
Impairment of PI3-K/Akt Pathway Underlies Attenuated Endothelial Function in Aorta of Type 2 Diabetic Mouse Model
TL;DR: The results suggest that relaxation responses and NO production mediated via the PI3-K/Akt pathway are decreased in this type 2 diabetic model, which may be a major cause of endothelial dysfunction (and the resulting hypertension) in type 2 diabetes.
Journal ArticleDOI
Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes
TL;DR: The results suggest that metformin improves endothelial functions in OLETF mesenteric arteries by suppressing vasoconstrictor prostanoids and by reducing oxidative stress within the timescale studied here.
Journal ArticleDOI
Lack of Insulin Receptor Substrate-2 Causes Progressive Neointima Formation in Response to Vessel Injury
Tetsuya Kubota,Naoto Kubota,Masao Moroi,Yasuo Terauchi,Tsuneo Kobayashi,Katsuo Kamata,Ryo Suzuki,Kazuyuki Tobe,Atsushi Namiki,Shinichi Aizawa,Ryozo Nagai,Takashi Kadowaki,Tetsu Yamaguchi +12 more
TL;DR: It is concluded that IRS‐2 is protective and retards the development of neointima formation in insulin‐resistant states.