T
Takeo Awaji
Researcher at Saitama Medical University
Publications - 39
Citations - 2946
Takeo Awaji is an academic researcher from Saitama Medical University. The author has contributed to research in topics: G protein-coupled receptor & Green fluorescent protein. The author has an hindex of 20, co-authored 39 publications receiving 2785 citations. Previous affiliations of Takeo Awaji include Niigata University & National Institute of Radiological Sciences.
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Journal ArticleDOI
Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120.
Akira Hirasawa,Keiko Tsumaya,Takeo Awaji,Susumu Katsuma,Tetsuya Adachi,Masateru Yamada,Yukihiko Sugimoto,Shunichi Miyazaki,Gozoh Tsujimoto,Gozoh Tsujimoto +9 more
TL;DR: It is shown that a G-protein-coupled receptor, GPR120, which is abundantly expressed in intestine, functions as a receptor for unsaturated long-chain FFAs and promotes the secretion of GLP-1 in vitro and in vivo, and increases circulating insulin.
Journal Article
Selective growth of human mast cells induced by Steel factor, IL-6, and prostaglandin E2 from cord blood mononuclear cells.
Hirohisa Saito,M. Ebisawa,Hiroshi Tachimoto,Michitaka Shichijo,Kazumi Fukagawa,Kenji Matsumoto,Yoji Iikura,Takeo Awaji,Gozoh Tsujimoto,M Yanagida,Hiroya Uzumaki,G Takahashi,Kohichiro Tsuji,Tatsutoshi Nakahata +13 more
TL;DR: Electron-microscopic analysis revealed that some of the cultured mast cells are morphologically mature since they filled with scroll granules and contained crystal granules.
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Ca2+ oscillation-inducing phospholipase C zeta expressed in mouse eggs is accumulated to the pronucleus during egg activation
Ayako Yoda,Shoji Oda,Tomohide Shikano,Zen Kouchi,Takeo Awaji,Hideki Shirakawa,Katsuyuki Kinoshita,Shunichi Miyazaki +7 more
TL;DR: PLC zeta is a strong candidate of the Ca(2+) oscillation-inducing sperm factor, which is introduced into the ooplasm upon sperm-egg fusion and concentrated to the pronucleus after inducing egg activation.
Journal ArticleDOI
Selective production of transgenic mice using green fluorescent protein as a marker
T Takada,K Iida,Takeo Awaji,K Itoh,R Takahashi,A Shibui,Kenichi Yoshida,Sumio Sugano,Gozoh Tsujimoto +8 more
TL;DR: A method to selectively produce transgenic mice using green fluorescent protein (GFP) as a marker was developed and PCR analysis showed 11 out of 12 mice (fetuses and newborn mice) were transgenic.
Journal ArticleDOI
Structure-Activity Relationships of GPR120 Agonists Based on a Docking Simulation
Qi Sun,Akira Hirasawa,Takafumi Hara,Ikuo Kimura,Tetsuya Adachi,Takeo Awaji,Masaji Ishiguro,Takayoshi Suzuki,Naoki Miyata,Gozoh Tsujimoto +9 more
TL;DR: It is shown that a docking simulation using a GPR120 homology model might be useful to predict the agonistic activity of compounds.