G
Gozoh Tsujimoto
Researcher at Kyoto University
Publications - 329
Citations - 20056
Gozoh Tsujimoto is an academic researcher from Kyoto University. The author has contributed to research in topics: Receptor & Gene expression. The author has an hindex of 71, co-authored 329 publications receiving 18303 citations. Previous affiliations of Gozoh Tsujimoto include Niigata University of Pharmacy and Applied Life Sciences & Medical Research Council.
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Journal ArticleDOI
Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120.
Akira Hirasawa,Keiko Tsumaya,Takeo Awaji,Susumu Katsuma,Tetsuya Adachi,Masateru Yamada,Yukihiko Sugimoto,Shunichi Miyazaki,Gozoh Tsujimoto,Gozoh Tsujimoto +9 more
TL;DR: It is shown that a G-protein-coupled receptor, GPR120, which is abundantly expressed in intestine, functions as a receptor for unsaturated long-chain FFAs and promotes the secretion of GLP-1 in vitro and in vivo, and increases circulating insulin.
Journal ArticleDOI
The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43
Ikuo Kimura,Kentaro Ozawa,Daisuke Inoue,Takeshi Imamura,Kumi Kimura,Takeshi Maeda,Kazuya Terasawa,Daiji Kashihara,Kanako Hirano,Taeko Tani,Tomoyuki Takahashi,Satoshi Miyauchi,Go Shioi,Hiroshi Inoue,Gozoh Tsujimoto +14 more
TL;DR: It is demonstrated that G PR43-deficient mice are obese on a normal diet, whereas mice overexpressing GPR43 specifically in adipose tissue remain lean even when fed a high-fat diet.
Journal ArticleDOI
Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)
Ikuo Kimura,Daisuke Inoue,Takeshi Maeda,Takafumi Hara,Atsuhiko Ichimura,Satoshi Miyauchi,Makio Kobayashi,Akira Hirasawa,Gozoh Tsujimoto +8 more
TL;DR: It is established that SCFAs and ketone bodies directly regulate GPR41-mediated SNS activity and thereby control body energy expenditure in maintaining metabolic homeostasis.
Journal ArticleDOI
Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1
TL;DR: It is shown that bile acids promote glucagon-like peptide-1 (GLP-1) secretion through TGR5 in a murine enteroendocrine cell line STC-1, and an adenylate cyclase inhibitor, MDL12330A, significantly suppressed bile acid-promoted GLP- 1 secretion.
Journal ArticleDOI
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human
Atsuhiko Ichimura,Akira Hirasawa,Odile Poulain-Godefroy,Odile Poulain-Godefroy,Amélie Bonnefond,Amélie Bonnefond,Takafumi Hara,Loic Yengo,Loic Yengo,Ikuo Kimura,Audrey Leloire,Audrey Leloire,Ning Liu,Keiko Iida,Hélène Choquet,Hélène Choquet,Philippe Besnard,Cécile Lecoeur,Cécile Lecoeur,Sidonie Vivequin,Sidonie Vivequin,Kumiko Ayukawa,Masato Takeuchi,Kentaro Ozawa,Maithé Tauber,Claudio Maffeis,Anita Morandi,Anita Morandi,Raffaella Buzzetti,Paul Elliott,Anneli Pouta,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Antje Körner,Wieland Kiess,Marie Pigeyre,Roberto Caiazzo,Wim Van Hul,Luc Van Gaal,Fritz F. Horber,Beverley Balkau,Claire Levy-Marchal,Konstantinos Rouskas,Konstantinos Rouskas,Konstantinos Rouskas,Anastasia Kouvatsi,Johannes Hebebrand,Anke Hinney,André Scherag,François Pattou,David Meyre,David Meyre,David Meyre,Taka-aki Koshimizu,Isabelle Wolowczuk,Isabelle Wolowczuk,Gozoh Tsujimoto,Philippe Froguel,Philippe Froguel,Philippe Froguel +59 more
TL;DR: This study demonstrates that the lipid sensor GPR120 has a key role in sensing dietary fat and, therefore, in the control of energy balance in both humans and rodents.